青光眼脉络膜微血管丢失和视网膜神经纤维层变化的比率。
Rates of Choroidal Microvasculature Dropout and Retinal Nerve Fiber Layer Changes in Glaucoma.
机构信息
From the Hamilton Glaucoma Center(E.M., S.M., T.N., N.E.N., G.M., A.K., L.M.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Narayana Nethralaya (H.L.R.), Bangalore, India; University Eye Clinic Maastricht (H.L.R.), University Medical Center, Maastricht, the Netherlands.
出版信息
Am J Ophthalmol. 2022 Sep;241:130-138. doi: 10.1016/j.ajo.2022.04.024. Epub 2022 May 10.
PURPOSE
To evaluate the association between rates of choroidal microvasculature dropout (MvD) change and rates of circumpapillary retinal nerve fiber layer (cpRNFL) loss in primary open-angle glaucoma (POAG) eyes.
DESIGN
Cohort study from clinical trial data.
METHODS
A total of 91 eyes of 68 POAG patients with and without localized MvD at baseline with at least 4 visits and 2 years of follow-up with optical coherence tomography angiography (OCT-A) and OCT scans were included. Area and angular circumference of MvD were evaluated on OCT-A en face and B-scan choroidal vessel density images during the follow-up period. Joint longitudinal mixed effects models were used to estimate the rates of change in MvD area or angular circumference and RNFL thickness. Univariable and multivariable regressions were completed to identify the factors contributing to cpRNFL thinning.
RESULTS
MvD was identified in 53 eyes (58.2%) at baseline. Seventeen eyes (18.6%) that did not show MvD at baseline developed it over the follow-up period. Over a mean follow-up of 4.0 years, the mean rates of change in MvD area and angular circumference (95% CI) were 0.05 (0.04, 0.06) mm per year and 13.2° (10.7°, 15.8°) per year, respectively. In multivariable models, the rate of cpRNFL thinning was significantly associated with the rates of change in MvD area and angular circumference (P = .008 and P = .009, respectively).
CONCLUSIONS
Rates of MvD area and angular circumference change over time were associated with concurrent rates of cpRNFL loss in POAG eyes.
目的
评估原发性开角型青光眼（POAG）患者脉络膜微血管丢失（MvD）变化率与周边视网膜神经纤维层（cpRNFL）丢失率之间的关系。
设计
来自临床试验数据的队列研究。
方法
共纳入 91 只眼的 68 例 POAG 患者，这些患者在基线时有局部 MvD，至少有 4 次随访和 2 年的光学相干断层扫描血管造影（OCT-A）和 OCT 扫描随访。在随访期间，通过 OCT-A 共面和 B 扫描脉络膜血管密度图像评估 MvD 区域和角周长。使用联合纵向混合效应模型来估计 MvD 区域或角周长和 RNFL 厚度的变化率。完成单变量和多变量回归，以确定导致 cpRNFL 变薄的因素。
结果
基线时有 53 只眼（58.2%）存在 MvD。17 只（18.6%）基线时未出现 MvD 的眼在随访期间出现了 MvD。在平均 4.0 年的随访中，MvD 区域和角周长的平均变化率（95%CI）分别为每年 0.05（0.04，0.06）mm 和每年 13.2°（10.7°，15.8°）。在多变量模型中，cpRNFL 变薄率与 MvD 区域和角周长的变化率显著相关（P=0.008 和 P=0.009）。
结论
随着时间的推移，MvD 区域和角周长的变化率与 POAG 眼同时发生的 cpRNFL 丢失率相关。
Zotero 插件