Falanga V, Moosa H H, Nemeth A J, Alstadt S P, Eaglstein W H
Arch Dermatol. 1987 May;123(5):620-3.
Pericapillary fibrin deposition is thought to contribute to the pathogenesis of venous ulceration. To our knowledge, however, there is no previous evidence that pericapillary fibrin is deposited in the tissue adjacent to venous ulcers. We prospectively studied patients with ulcers of the lower extremities for the presence of dermal pericapillary fibrin in the skin adjacent tot he ulcers. On direct immunofluorescence, pericapillary fibrin was found in 14 (93%) of the 15 patients with venous ulceration but in only one (7%) of the 14 subjects with ulcers due to other causes. We also confirmed the presence of dermal pericapillary fibrin in legs with venous disease without ulcerations. We conclude that the pericapillary fibrin is easily demonstrable in the dermis adjacent to venous ulcers. In the evaluation of ulcers due to uncertain causes, the presence of dermal pericapillary fibrin may provide additional diagnostic help.
毛细血管周围纤维蛋白沉积被认为与静脉溃疡的发病机制有关。然而，据我们所知，此前尚无证据表明毛细血管周围纤维蛋白沉积于静脉溃疡附近的组织中。我们对下肢溃疡患者进行了前瞻性研究，以检测溃疡附近皮肤中真皮毛细血管周围纤维蛋白的存在情况。直接免疫荧光检查发现，15例静脉溃疡患者中有14例（93%）存在毛细血管周围纤维蛋白，而14例其他原因导致溃疡的患者中只有1例（7%）存在。我们还证实，无溃疡的静脉疾病患者腿部也存在真皮毛细血管周围纤维蛋白。我们得出结论，在静脉溃疡附近的真皮中很容易检测到毛细血管周围纤维蛋白。在评估病因不明的溃疡时，真皮毛细血管周围纤维蛋白的存在可能会提供额外的诊断帮助。
