肾素-血管紧张素系统在肾素状态各异的正常血压和高血压大鼠中的作用。
The role of the renin-angiotensin system in normotensive and hypertensive rats with varying renin status.
作者信息
Atkinson J, Boillat N, Essadki A, Lüthi P, Maranda B, Sonnay M
出版信息
Arch Int Pharmacodyn Ther. 1987 Feb;285(2):301-15.
PMID:3555376
Abstract
We have investigated the relationship between the acute blood pressure lowering effect of captopril and renin status. Differences in renin status were induced by unilateral artery clipping combined with unilateral or bilateral nephrectomy in rats. The blood pressure lowering effect of captopril correlated very closely with plasma or aortic renin across a very wide range of renin levels.
摘要
我们研究了卡托普利的急性降压作用与肾素状态之间的关系。通过对大鼠进行单侧动脉夹闭联合单侧或双侧肾切除术来诱导肾素状态的差异。在非常广泛的肾素水平范围内，卡托普利的降压作用与血浆或主动脉肾素密切相关。
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