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肾素-血管紧张素系统在肾素状态各异的正常血压和高血压大鼠中的作用。

The role of the renin-angiotensin system in normotensive and hypertensive rats with varying renin status.

作者信息

Atkinson J, Boillat N, Essadki A, Lüthi P, Maranda B, Sonnay M

出版信息

Arch Int Pharmacodyn Ther. 1987 Feb;285(2):301-15.

PMID:3555376
Abstract

We have investigated the relationship between the acute blood pressure lowering effect of captopril and renin status. Differences in renin status were induced by unilateral artery clipping combined with unilateral or bilateral nephrectomy in rats. The blood pressure lowering effect of captopril correlated very closely with plasma or aortic renin across a very wide range of renin levels.

摘要

我们研究了卡托普利的急性降压作用与肾素状态之间的关系。通过对大鼠进行单侧动脉夹闭联合单侧或双侧肾切除术来诱导肾素状态的差异。在非常广泛的肾素水平范围内，卡托普利的降压作用与血浆或主动脉肾素密切相关。

相似文献

1
The role of the renin-angiotensin system in normotensive and hypertensive rats with varying renin status.肾素-血管紧张素系统在肾素状态各异的正常血压和高血压大鼠中的作用。
Arch Int Pharmacodyn Ther. 1987 Feb;285(2):301-15.
2
Effect of 12-hour infusions of saralasin or captopril on blood pressure in hypertensive conscious rats. Relationship to plasma renin, duration of hypertension, and effect of unclipping.在清醒高血压大鼠中，静脉输注沙拉新或卡托普利12小时对血压的影响。与血浆肾素、高血压病程以及解除夹闭的效应的关系。
J Lab Clin Med. 1981 Aug;98(2):302-10.
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Angiotensin II is a necessary component for the development of hypertension in the two kidney, one clip rat.血管紧张素II是二肾一夹大鼠高血压发展的必要组成部分。
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Involvement of the renin-angiotensin system in the dipsogenic effect of morphine.肾素-血管紧张素系统在吗啡致渴作用中的参与。
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Angiotensin-converting enzyme inhibition with quinapril (CI-906) and captopril in spontaneously hypertensive rats with suppressed renin-angiotensin system.用喹那普利（CI-906）和卡托普利对肾素-血管紧张素系统受抑制的自发性高血压大鼠进行血管紧张素转换酶抑制作用研究。
Methods Find Exp Clin Pharmacol. 1987 Jun;9(6):325-31.
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Role of the renin-system in normo- and hypertension. Effect of angiotensin-inhibitor (1-sar-8-ala-angiotensin II) on the blood pressure of conscious or anaesthetized normal, nephrectomized and renal hypertensive rats.肾素系统在正常血压和高血压中的作用。血管紧张素抑制剂（1-肌氨酸-8-丙氨酸血管紧张素II）对清醒或麻醉的正常大鼠、肾切除大鼠和肾性高血压大鼠血压的影响。
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Angiotensin I and II disappear completely from circulating blood within 48 hours after binephrectomy: improved measurement of angiotensins in rat plasma.
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Effect of DOCA-salt on angiotensin dependency and surgical reversal of hypertension in two-kidney, one clip renal hypertensive rats.去氧皮质酮盐对两肾一夹肾性高血压大鼠血管紧张素依赖性及高血压手术逆转的影响
J Hypertens. 1983 Jun;1(1):57-63.

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