来自脂多糖无反应性C3H/HeJ小鼠的血清不支持功能性EAC试剂的形成。
Serum from LPS nonresponder C3H/HeJ mice does not support the formation of functional EAC reagents.
作者信息
Hoffmann M K
出版信息
J Immunol. 1978 Aug;121(2):619-21.
PMID:355548
Abstract
Serum from C3H/HeJ mice in contrast to serum from other mouse strains does not convert EA into EAC. A factor in supportive serum permits nonsupportive C3H/HeJ serum to produce a functional EAC-rosetting reagent. This factor is heat stable. Its concentration in serum parallels the sensitivity of mice to LPS. It is absent or inoperative when sensitivity is reduced on a genetic basis and increased when sensitivity is increased by treatment with BCG.
摘要
与其他小鼠品系的血清不同，C3H/HeJ小鼠的血清不能将EA转化为EAC。支持性血清中的一种因子可使无支持作用的C3H/HeJ血清产生功能性EAC花环形成试剂。该因子对热稳定。其在血清中的浓度与小鼠对LPS的敏感性平行。当敏感性因遗传因素而降低时，该因子不存在或不起作用；而当通过卡介苗治疗使敏感性增加时，该因子则会增加。
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