Odetola Segun Samson, Ajani Mustapha Akanji, Iyapo Oluwadamilare, Salami Ayodeji A, Okolo Clement Abu
Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria.
Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
J West Afr Coll Surg. 2020 Apr-Jun;10(2):1-4. doi: 10.4103/jwas.jwas_1_22. Epub 2022 Mar 26.
Endometrial carcinoma is the commonest genital tract malignancy in most developed nations, but it lags behind cervical carcinoma and ovarian cancers in most developing nations including Nigeria. Estrogen has been described as a promoter of endometrial carcinogenesis.
The aim of this study was to demonstrate the frequency of estrogen receptor (ER) and progesterone receptor (PR) expressions of endometrial carcinoma and to correlate it with tumour grade.
Cases of endometrial carcinoma diagnosed in the Department of Pathology over a 10-year period were reviewed retrospectively. The paraffin-embedded blocks were retrieved, and immunohistochemistry for ER and PR was performed on them. Haematoxylin and eosin (H&E) slides were reviewed, and tumours were graded by three independent pathologists. Data were analysed using SPSS version 22. The level of significance was set at ≤ 0.05.
There were 44 cases of endometrial carcinoma. ER and PR were positive in 29.5% and 18.2% of endometrial carcinoma, respectively. There was no significant association between ER ( = 0.361) and PR ( = 0.204) expressions and histological grade of the tumour. The most common histological grade was grade 3 with 70% of cases (36 cases), whereas 13 cases (26%) were grade 2 and only 2 cases (4%) were grade 1.
The positive expressions of ER and PR in endometrial carcinoma suggest that steroid receptor studies may be of potential benefit in the management of some patients with endometrial carcinoma. Future studies employing larger sample size are therefore recommended.
子宫内膜癌是大多数发达国家最常见的生殖道恶性肿瘤，但在包括尼日利亚在内的大多数发展中国家，它落后于宫颈癌和卵巢癌。雌激素被认为是子宫内膜癌发生的促进因素。
本研究旨在证实子宫内膜癌中雌激素受体（ER）和孕激素受体（PR）表达的频率，并将其与肿瘤分级相关联。
回顾性分析病理科在10年期间诊断的子宫内膜癌病例。检索石蜡包埋块，并对其进行ER和PR的免疫组织化学检测。复查苏木精和伊红（H&E）切片，由三位独立的病理学家对肿瘤进行分级。使用SPSS 22版软件进行数据分析。显著性水平设定为≤0.05。
共有44例子宫内膜癌病例。ER和PR在子宫内膜癌中的阳性率分别为29.5%和18.2%。ER（=0.361）和PR（=0.204）表达与肿瘤组织学分级之间无显著相关性。最常见的组织学分级为3级，占70%（36例），而13例（26%）为2级，仅2例（4%）为1级。
子宫内膜癌中ER和PR的阳性表达表明，类固醇受体研究可能对部分子宫内膜癌患者的治疗具有潜在益处。因此，建议未来开展更大样本量的研究。
