沉默TRIM37可抑制非小细胞肺癌细胞的增殖和迁移。

Silencing TRIM37 inhibits the proliferation and migration of non-small cell lung cancer cells.

作者信息

Ding Yi, Lu Yi, Xie Xinjie, Sheng Bo, Wang Zuopei

机构信息

Department of Thoracic Surgery, Shanghai Pudong New District People's Hospital No. 490 of Chuanhuan South Road Shanghai 201299 China

出版信息

RSC Adv. 2018 Oct 31;8(64):36852-36857. doi: 10.1039/c8ra06391e. eCollection 2018 Oct 26.

Tripartite motif containing 37 (TRIM37), a member of the tripartite motif (TRIM) family, has been involved in the development and progression of several tumors. However, its role in non-small cell lung cancer (NSCLC) is still unclear. Therefore, the aim of this study was to investigate the expression pattern and role of TRIM37 in NSCLC. Our results showed that TRIM37 was highly expressed in human NSCLC cell lines. Knockdown of TRIM37 obviously inhibited the proliferation and xenografted tumor growth Furthermore, knockdown of TRIM37 suppressed NSCLC cell migration and invasion by inhibiting the epithelial-mesenchymal transition (EMT) phenotype. Lastly, knockdown of TRIM37 greatly down-regulated the protein expression levels of β-catenin, cyclinD1 and c-myc in A549 cells. In conclusion, the present study revealed that TRIM37 plays an important role in the development and progression of NSCLC. Thus, TRIM37 may act a potential therapeutic target for treating NSCLC.

含三联基序蛋白37（TRIM37）是三联基序（TRIM）家族的成员之一，已被证实参与多种肿瘤的发生发展过程。然而，其在非小细胞肺癌（NSCLC）中的作用仍不清楚。因此，本研究旨在探讨TRIM37在NSCLC中的表达模式及其作用。我们的研究结果表明，TRIM37在人NSCLC细胞系中高表达。敲低TRIM37明显抑制了细胞增殖和异种移植瘤的生长。此外，敲低TRIM37通过抑制上皮-间质转化（EMT）表型抑制了NSCLC细胞的迁移和侵袭。最后，敲低TRIM37显著下调了A549细胞中β-连环蛋白、细胞周期蛋白D1和c-myc的蛋白表达水平。总之，本研究揭示了TRIM37在NSCLC的发生发展过程中起重要作用。因此，TRIM37可能是治疗NSCLC的一个潜在治疗靶点。