Xin Lingli, Ye Mei, Yang Lina, Chen Ling, Wang Lirong, Hou Qingxiang
Department of Graduate Administration, General Hospital of Chinese PLA Beijing 100853, China.
Department of Obstetrics and Gynecology, PLA Rocket Force Characteristic Medical Center Xinjiekou Outer Street 16#, Xicheng District, Beijing 100088, China.
Am J Transl Res. 2022 Apr 15;14(4):2343-2349. eCollection 2022.
To evaluate the effects of vasopressin injection technique (VIT) on ovarian reserve in laparoscopic cystectomy of bilateral ovarian endometrioma.
A total of 122 patients with bilateral ovarian endometrioma undergoing laparoscopic cystectomy were assigned to control or the VIT group. Coagulation-event count and blood loss were recorded. Levels of serum anti-Müllerian hormone (AMH) were assessed at 1 day pre-operation, 1 month, 3 months, and 6 months post-operation. The follicles in the tissue sections were counted, and the maximum thickness of cyst wall was measured.
Coagulation-event count and blood loss in the VIT group were statistically less than those in control group (P<0.05). In both groups, AMH levels at pre-operation were the highest among different time-points (P<0.05); a remarkable decrease of AMH level was observed at 1 month post-operation, and the values were the lowest among different time-points (P<0.05). At 3 months post-operation, AMH levels gradually increased to approximately 60% of those at pre-operation (P<0.05); at 6 months post-operation, AMH levels were significantly higher than those at 3 months post-operation in VIT group (P<0.05). AMH levels in VIT group were significantly higher than those in control group at each time-point post-operation (P<0.05). The cyst walls in control group were statistically thicker than those in VIT group (P<0.05). Consistent with results of cyst wall thickness, numbers of total follicle loss, primordial and primary follicles in VIT group were less than those of control group (P<0.05).
VIT effectively protected ovarian reserve in laparoscopic cystectomy of bilateral ovarian endometrioma.
评估血管加压素注射技术（VIT）对双侧卵巢子宫内膜异位囊肿腹腔镜切除术患者卵巢储备功能的影响。
选取122例行双侧卵巢子宫内膜异位囊肿腹腔镜切除术的患者，分为对照组和VIT组。记录凝血事件计数和失血量。于术前1天、术后1个月、3个月和6个月评估血清抗苗勒管激素（AMH）水平。对组织切片中的卵泡进行计数，并测量囊肿壁的最大厚度。
VIT组的凝血事件计数和失血量在统计学上低于对照组（P<0.05）。两组中，术前的AMH水平在不同时间点中最高（P<0.05）；术后1个月观察到AMH水平显著下降，且该值在不同时间点中最低（P<0.05）。术后3个月，AMH水平逐渐升至术前水平的约60%（P<0.05）；术后6个月，VIT组的AMH水平显著高于术后3个月（P<0.05）。术后各时间点VIT组的AMH水平均显著高于对照组（P<0.05）。对照组的囊肿壁在统计学上比VIT组更厚（P<0.05）。与囊肿壁厚度结果一致，VIT组的总卵泡丢失数、原始卵泡和初级卵泡数均少于对照组（P<0.05）。
VIT在双侧卵巢子宫内膜异位囊肿腹腔镜切除术中有效保护了卵巢储备功能。
