Attallah A A
Clin Sci (Lond). 1987 May;72(5):605-9. doi: 10.1042/cs0720605.
The effects of chronic alterations in dietary sodium intake on urinary prostaglandin (PG) E2 and thromboxane (TX) B2 was investigated in the rabbit. Sodium restriction, over a 15-day period, reduced daily urinary PGE2 and TXB2 in concordance with urinary flow (V) and sodium excretion (UNa+V), but increased plasma renin activity (PRA) and plasma aldosterone concentration (PAC). Sodium repletion, on the other hand, increased urinary PGE2 and TXB2 in proportion to the rise in V, but reduced PRA and PAC. During both sodium diets PGE2 and TXB2 correlated positively with V and negatively with PRA. It is concluded that chronic sodium intake produces opposite changes in the renal prostaglandin and the renin-angiotensin systems.
研究了家兔饮食中钠摄入量的长期变化对尿前列腺素（PG）E2和血栓素（TX）B2的影响。在15天的时间里，钠限制使每日尿PGE2和TXB2与尿流率（V）和钠排泄量（UNa+V）一致地减少，但增加了血浆肾素活性（PRA）和血浆醛固酮浓度（PAC）。另一方面，钠补充使尿PGE2和TXB2与V的升高成比例增加，但降低了PRA和PAC。在两种钠饮食期间，PGE2和TXB2与V呈正相关，与PRA呈负相关。结论是，长期钠摄入会使肾脏前列腺素系统和肾素-血管紧张素系统产生相反的变化。
