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人垂体血液中的促黄体生成激素释放激素

Luteinizing hormone-releasing hormone in human pituitary blood.

作者信息

Antunes J L, Carmel P W, Housepian E M, Ferin M

出版信息

J Neurosurg. 1978 Sep;49(3):382-6. doi: 10.3171/jns.1978.49.3.0382.

DOI:10.3171/jns.1978.49.3.0382
PMID:355605
Abstract

Luteinizing hormone (LH) and LH-releasing hormone (LHRH) were measured by radioimmunoassay in blood samples collected from the pituitary gland during transsphenoidal surgery in 19 patients. Detectable levels of LHRH were present in 12 patients. Wide fluctuations of LHRH were seen in sequential samples collected at 10-minute intervals, suggesting a pulsatile mode of release. This technique may yield useful data on hypothalamic control of pituitary secretion.

摘要

采用放射免疫分析法对19例经蝶窦手术患者垂体采集的血样中的促黄体生成素（LH）和促黄体生成素释放激素（LHRH）进行了检测。12例患者血样中可检测到LHRH。每隔10分钟采集的连续样本中LHRH出现大幅波动，提示其释放呈脉冲模式。该技术可能会产生有关下丘脑对垂体分泌控制的有用数据。

相似文献

1
Luteinizing hormone-releasing hormone in human pituitary blood.人垂体血液中的促黄体生成激素释放激素
J Neurosurg. 1978 Sep;49(3):382-6. doi: 10.3171/jns.1978.49.3.0382.
2
The response of pituitary gonadotropes to a constant infusion of luteinizing hormone-releasing hormone (LHRH) in normal prepubertal and pubertal children and in children with abnormalities of sexual development.正常青春期前和青春期儿童以及性发育异常儿童的垂体促性腺细胞对持续输注促黄体生成素释放激素（LHRH）的反应。
J Clin Endocrinol Metab. 1976 Aug;43(2):400-11. doi: 10.1210/jcem-43-2-400.
3
Estrogen inhibits luteinizing hormone (LH), but not follicle-stimulating hormone secretion in hypophysectomized pituitary-grafted rats receiving pulsatile LH-releasing hormone infusions.在接受脉冲式促黄体生成激素释放激素输注的垂体移植去垂体大鼠中，雌激素抑制促黄体生成激素（LH）分泌，但不抑制促卵泡激素分泌。
Endocrinology. 1988 Jul;123(1):622-30. doi: 10.1210/endo-123-1-622.
4
Castration induces luteinizing hormone (LH) secretion in hypophysectomized pituitary-grafted rats receiving pulsatile LH-releasing hormone infusions.阉割可诱导接受脉冲式促黄体生成素释放激素输注的垂体移植去垂体大鼠分泌促黄体生成素（LH）。
Endocrinology. 1989 Mar;124(3):1140-4. doi: 10.1210/endo-124-3-1140.
5
In vitro release of lutenizing hormone from anterior pituitary fragments superfused with constant or pulsatile amounts of luteinizing hormone-releasing factor.
Endocrinology. 1975 May;96(5):1210-15. doi: 10.1210/endo-96-5-1210.
6
Hyperprolactinemia decreases the luteinizing hormone-releasing hormone concentration in pituitary portal plasma: a possible role for beta-endorphin as a mediator.
Endocrinology. 1985 May;116(5):2080-4. doi: 10.1210/endo-116-5-2080.
7
Simultaneous measurement of luteinizing hormone (LH)-releasing hormone, LH, and follicle-stimulating hormone release in intact and short-term castrate rats.完整和短期去势大鼠中促黄体生成激素（LH）释放激素、LH及促卵泡激素释放的同步测定
Endocrinology. 1988 May;122(5):2211-21. doi: 10.1210/endo-122-5-2211.
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Changes in pulsatile release of neuropeptide-Y and luteinizing hormone (LH)-releasing hormone during the progesterone-induced LH surge in rhesus monkeys.恒河猴在孕酮诱导促黄体生成素（LH）峰期间神经肽Y和促黄体生成素释放激素（LH-RH）脉冲式释放的变化。
Endocrinology. 1994 Oct;135(4):1679-86. doi: 10.1210/endo.135.4.7925132.
9
Ovarian steroids directly alter luteinizing hormone (LH) release by pituitary homografts.卵巢甾体激素可直接改变垂体移植组织中促黄体生成素（LH）的释放。
Endocrinology. 1975 Jul;97(1):196-201. doi: 10.1210/endo-97-1-196.
10
Effect of protein deficiency on luteinizing hormone releasing hormone (LHRH), gonadotropin releasing hormone associated peptide (GAP) and luteinizing hormone (LH) immunocytochemistry in the hypothalamus and pituitary gland of prepubertal ewes.蛋白质缺乏对青春期前母羊下丘脑和垂体中促黄体生成素释放激素（LHRH）、促性腺激素释放激素相关肽（GAP）及促黄体生成素（LH）免疫细胞化学的影响。
Exp Clin Endocrinol. 1993;101(4):230-7. doi: 10.1055/s-0029-1211237.

引用本文的文献

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Horm Behav. 2022 Sep;145:105230. doi: 10.1016/j.yhbeh.2022.105230. Epub 2022 Jul 6.
2
Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications.促性腺激素释放激素肽（kisspeptin）可恢复神经激肽 B 信号缺陷患者的促黄体生成素脉冲式分泌：生理、病理生理和治疗意义。
Neuroendocrinology. 2013;97(2):193-202. doi: 10.1159/000336376. Epub 2012 Feb 24.
3
Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons.
人类 GnRH 缺乏症：揭示 GnRH 神经元发生的独特疾病模型。
Neuroendocrinology. 2010;92(2):81-99. doi: 10.1159/000314193. Epub 2010 Jul 7.
4
Induction of ovulation with chronic intermittent (pulsatile) administration of LH-RH in women with hypothalamic and hyperprolactinemic amenorrhea.在下丘脑性和高泌乳素血症性闭经女性中，采用慢性间歇性（脉冲式）给予促黄体生成素释放激素（LH-RH）诱导排卵。
Arch Gynecol. 1980;229(3):177-90. doi: 10.1007/BF02108310.
5
High concentrations of catecholamines in human hypothalamic-hypophysial blood.
J Clin Invest. 1989 Jun;83(6):2079-84. doi: 10.1172/JCI114120.
6
Immunofluorescence study of the preoptico-terminal LRH tract in the female squirrel monkey during the estrous cycle.雌性松鼠猴发情周期中视前区-终纹床核促性腺激素释放激素通路的免疫荧光研究。
Cell Tissue Res. 1979 Apr 30;198(1):1-13. doi: 10.1007/BF00234829.