McFadden E R
Chest. 1987 Jun;91(6 Suppl):151S-157S.
Airflow limitation in exercise-induced asthma is related to the thermal events in the intrathoracic airways. This article reviews the present knowledge about the exchange of respiratory heat and water. The evidence for the various theories proposed for the basic mechanisms involved in exercise-induced asthma are discussed. The evidence suggests that exercise-induced airways obstruction may be a vascular phenomenon dependent on the rapidity and magnitude of airway rewarming. Obstruction is induced if a thermal gradient exists at the end of exercise and the greater the gradient the greater the resultant hyperemia and edema. The basic mechanism of control of reactivity is still not known and directions for future research are outlined.
运动诱发性哮喘中的气流受限与胸内气道的热事件有关。本文综述了目前关于呼吸热和水交换的知识。讨论了针对运动诱发性哮喘所涉及的基本机制提出的各种理论的证据。证据表明，运动诱发的气道阻塞可能是一种依赖于气道复温速度和幅度的血管现象。如果运动结束时存在热梯度，就会诱发阻塞，梯度越大，由此产生的充血和水肿就越严重。反应性控制的基本机制仍然未知，并概述了未来的研究方向。
