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Inhibition of ferroptosis promotes megakaryocyte differentiation and platelet production.

作者信息

Song Baoquan, Miao Wenjing, Cui Qingya, Shi Bingyu, Zhang Jian, Qiu Huiying, Zhang Leisheng, Han Yue

机构信息

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China.

出版信息

J Cell Mol Med. 2022 Jun;26(12):3582-3585. doi: 10.1111/jcmm.17289. Epub 2022 May 13.

DOI:10.1111/jcmm.17289
PMID:35560727
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9189328/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87aa/9189328/5f9384221928/JCMM-26-3582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87aa/9189328/0b85e4c935f4/JCMM-26-3582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87aa/9189328/5f9384221928/JCMM-26-3582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87aa/9189328/0b85e4c935f4/JCMM-26-3582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87aa/9189328/5f9384221928/JCMM-26-3582-g002.jpg

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Am J Hematol. 2021 Aug 1;96(8):1008-1016. doi: 10.1002/ajh.26189. Epub 2021 May 14.
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Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice.缺铁促进人类和小鼠巨核细胞-红系祖细胞向巨核细胞方向分化。
Blood. 2019 Oct 31;134(18):1547-1557. doi: 10.1182/blood.2019002039.
3
Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis.脂质过氧化和 GPX4 抑制是肌成纤维细胞分化和铁死亡的常见原因。
人类红细胞生成过程中的细胞死亡信号传导：红细胞成熟后失去了细胞死亡机制的复杂性。
Apoptosis. 2025 Apr;30(3-4):652-673. doi: 10.1007/s10495-025-02081-5. Epub 2025 Feb 9.
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Thrombocytopenia in Severe Fever with Thrombocytopenia Syndrome Due to Platelets With Altered Function Undergoing Cell Death Pathways.血小板功能改变并经历细胞死亡途径导致严重发热伴血小板减少综合征中的血小板减少症
J Infect Dis. 2025 Feb 4;231(1):e183-e194. doi: 10.1093/infdis/jiae355.
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Lysophosphatidic Acid Receptor 3 Activation Is Involved in the Regulation of Ferroptosis.溶血磷脂酸受体 3 的激活参与铁死亡的调控。
Int J Mol Sci. 2024 Feb 15;25(4):2315. doi: 10.3390/ijms25042315.
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Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia.铁死亡的分子机制及在癌症和白血病中铁死亡研究的新进展。
Cells. 2023 Apr 11;12(8):1128. doi: 10.3390/cells12081128.
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