单细胞分辨率的小鼠器官发生图谱。

Mouse organogenesis atlas at single-cell resolution.

机构信息

Computational Systems Biology Group, Children's Medical Research Institute, Sydney, NSW, Australia; School of Mathematics and Statistics, Faculty of Science, University of Sydney, Sydney, NSW, Australia.

Embryology Research Unit, Children's Medical Research Institute, Sydney, NSW, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

出版信息

Cell. 2022 May 12;185(10):1625-1627. doi: 10.1016/j.cell.2022.04.026.

DOI:10.1016/j.cell.2022.04.026

PMID:35561663

Abstract

The generation of spatial transcriptomes of whole embryo has been limited in scale and resolution due to various technological restrictions. In this issue of Cell, Chen et al. introduce a DNA nanoball-based sample-capture technology for spatial transcriptome analysis to generate a molecular atlas of mouse organogenesis at single-cell resolution.

摘要

由于各种技术限制，全胚胎空间转录组的生成在规模和分辨率上一直受到限制。在本期《细胞》杂志上，Chen 等人介绍了一种基于 DNA 纳米球的样本捕获技术，用于空间转录组分析，以单细胞分辨率生成小鼠器官发生的分子图谱。