Jaillon P
Eur Heart J. 1987 Mar;8 Suppl A:127-32. doi: 10.1093/eurheartj/8.suppl_a.127.
Most cardiac patients who have cardiac arrhythmias and are treated by antiarrhythmic agents will receive other cardiovascular drugs to treat coexistent problems, for example heart failure, angina or hypertension. Also, two antiarrhythmic drugs may be simultaneously prescribed to these patients in the search for better efficacy and fewer side effects. Finally these patients may well take noncardiovascular drugs such as cimetidine for the treatment of peptic ulcer disease or other hypersecretory disorders. In all cases, complex pharmacodynamic and pharmacokinetic drug interactions are likely to occur. These interactions have been extensively reviewed by Bigger and Giardina. The purpose of this work is to focus on the potentially important interactions with antiarrhythmic drugs. It is of interest for the cardiologist to be aware of the most common and meaningful drug interactions in order to prevent lack of efficacy or a risk of drug toxicity that could result from the simultaneous administration of different drugs to a patient. In this regard the interactions of antiarrhythmic drugs with digitalis, cimetidine, beta-blocking agents and other antiarrhythmic drugs will be briefly reviewed.
大多数患有心律失常且接受抗心律失常药物治疗的心脏病患者会同时服用其他心血管药物来治疗并存的问题，例如心力衰竭、心绞痛或高血压。此外，为了寻求更好的疗效和更少的副作用，可能会同时给这些患者开两种抗心律失常药物。最后，这些患者很可能会服用非心血管药物，如西咪替丁，用于治疗消化性溃疡疾病或其他分泌过多性疾病。在所有这些情况下，都可能发生复杂的药效学和药代动力学药物相互作用。比格和贾尔迪纳对这些相互作用进行了广泛的综述。这项工作的目的是关注与抗心律失常药物潜在的重要相互作用。心脏病专家了解最常见且有意义的药物相互作用很有必要，这样可以防止因同时给患者使用不同药物而导致疗效不佳或药物毒性风险。在这方面，将简要回顾抗心律失常药物与洋地黄、西咪替丁、β受体阻滞剂及其他抗心律失常药物的相互作用。
