Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum, Kerala, India.
Indian J Pathol Microbiol. 2022 May;65(Supplement):S176-S188. doi: 10.4103/ijpm.ijpm_1026_21.
Epilepsy surgery is a well-established treatment modality in selected cases of medically refractory epilepsy. Advances in neuroimaging technology has greatly facilitated detection of lesions that are surgically amenable. Hippocampal sclerosis is the most common pathology encountered among specimens from epilepsy-related surgeries. Other common pathologies are malformations of cortical development including focal cortical dysplasia, neoplasms, vascular malformations, inflammatory conditions including Rasmussen encephalitis and glial scars. Proper handling of surgical specimens is necessary for microscopic evaluation. Accurate interpretation and classification of lesions will help define clinically relevant etiologies. In this review, neuropathological aspects of the common etiologies underlying drug-resistant epilepsies are discussed.
癫痫手术是一种经过充分验证的治疗方法，适用于特定的药物难治性癫痫病例。神经影像学技术的进步极大地促进了对可手术治疗病变的检测。海马硬化是癫痫相关手术标本中最常见的病变。其他常见的病变包括局灶性皮质发育不良等皮质发育畸形、肿瘤、血管畸形、炎症性疾病如拉塞尔氏脑炎和神经胶质瘢痕。手术标本的正确处理对于显微镜评估是必要的。准确解释和分类病变有助于确定具有临床意义的病因。在这篇综述中，讨论了导致耐药性癫痫的常见病因的神经病理学方面。
