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对于子宫内膜异位症,膀胱切除术和 CO2 激光汽化术的长期复发率相似:一项回顾性研究。

Similar long-term recurrence rates with cystectomy and CO laser vaporization for endometrioma: a retrospective study.

机构信息

Department of Obstetrics and Gynecology, Leuven University Fertility Center, University Hospitals Leuven, Leuven 3000, Belgium; Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven 3000, Belgium.

Department of Obstetrics and Gynecology, Leuven University Fertility Center, University Hospitals Leuven, Leuven 3000, Belgium.

出版信息

Reprod Biomed Online. 2022 Jul;45(1):101-108. doi: 10.1016/j.rbmo.2022.02.024. Epub 2022 Mar 3.

Abstract

RESEARCH QUESTION

Is there a difference in recurrence rate of endometrioma(s) after cystectomy versus CO laser vaporization of the cyst wall?

DESIGN

This single-centre retrospective study included 270 patients undergoing laparoscopic surgery for endometriomas between January 2010 and December 2014, stratified according to the surgical technique used. All 270 included patients underwent complete laparoscopic surgery for endometrioma(s): 155 underwent cystectomy, 63 complete CO laser vaporization of the cyst wall and 52 a mixed technique. The primary outcome studied was the difference in recurrence rate between the cystectomy group and the CO laser vaporization group.

RESULTS

The mean duration of follow-up was 58 (±34) months. Imaging-based recurrence (any cyst size) was reported in 9.9% of patients (n = 12/121) treated with cystectomy and in 13.3% of patients (n = 6/45) who underwent a vaporization (P = 0.577). The need for reintervention for endometrioma(s) was also similar in both groups, with a rate of 3.2% (n = 5/155) after cystectomy and 4.8% (n = 3/63) after vaporization (P = 0.476). Of 160 women who wanted to conceive immediately after surgery, 73.8% became pregnant (72.6% [77/106] in the cystectomy group and 75.9% [41/54] in the vaporization group [P = 0.310]). Conception occurred mostly by assisted reproductive technology (57.1% [44/77] in the cystectomy group and 70.7% [29/41] in the vaporization group [P = 0.074]).

CONCLUSIONS

Similar rates of recurrence for endometrioma(s) were observed after cystectomy versus CO laser vaporization. As other studies have suggested that CO laser vaporization may be less harmful to the normal ovarian tissue, it can be considered as a safe alternative for cystectomy in women wishing to preserve their reproductive potential.

摘要

研究问题

囊壁切除术与 CO2 激光汽化术治疗卵巢子宫内膜异位囊肿后,囊肿复发率是否存在差异?

设计

本单中心回顾性研究纳入了 2010 年 1 月至 2014 年 12 月间因卵巢子宫内膜异位囊肿接受腹腔镜手术的 270 例患者,根据手术方式进行分层。所有 270 例患者均接受完整的腹腔镜手术治疗:155 例行囊肿切除术,63 例行 CO2 激光汽化术,52 例行混合手术。主要研究结局为囊肿切除术组与 CO2 激光汽化术组的复发率差异。

结果

中位随访时间为 58(±34)个月。影像学提示囊肿复发(任何囊肿大小)见于囊肿切除术组 9.9%(n=12/121)的患者和 CO2 激光汽化术组 13.3%(n=6/45)的患者(P=0.577)。两组的囊肿再次手术率也相似,囊肿切除术组为 3.2%(n=5/155),CO2 激光汽化术组为 4.8%(n=3/63)(P=0.476)。160 名希望术后立即妊娠的患者中,73.8%妊娠(囊肿切除术组 72.6%[77/106],CO2 激光汽化术组 75.9%[41/54],P=0.310)。妊娠主要通过辅助生殖技术(ART)实现(囊肿切除术组 57.1%[44/77],CO2 激光汽化术组 70.7%[29/41],P=0.074)。

结论

囊肿切除术与 CO2 激光汽化术治疗卵巢子宫内膜异位囊肿后,囊肿复发率相似。如其他研究所述,CO2 激光汽化术对正常卵巢组织的损伤可能较小,因此对于希望保留生育能力的女性,CO2 激光汽化术可以作为囊肿切除术的一种安全替代方法。

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