Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, Strzody 9 Str., 44-100 Gliwice, Poland.
Department of Inorganic Chemistry, Analytical Chemistry and Electrochemistry, Faculty of Chemistry, Silesian University of Technology, Krzywoustego 6 Str., 44-100 Gliwice, Poland.
Int J Mol Sci. 2022 Apr 29;23(9):4954. doi: 10.3390/ijms23094954.
The growing scale of secondary caries and occurrence of antibiotic-resistant bacterial strains require the development of antibacterial dental composites. It can be achieved by the chemical introduction of quaternary ammonium dimethacrylates into dental composites. In this study, physicochemical and antibacterial properties of six novel copolymers consisting of 60 wt. % quaternary ammonium urethane-dimethacrylate analogues (QAUDMA) and 40 wt. % triethylene glycol dimethacrylate (TEGDMA) were investigated. Uncured compositions had suitable refractive index (), density (), and glass transition temperature (). Copolymers had low polymerization shrinkage (), high degree of conversion () and high glass transition temperature (). They also showed high antibacterial effectiveness against and bacterial strains. It was manifested by the reduction in cell proliferation, decrease in the number of bacteria adhered on their surfaces, and presence of growth inhibition zones. It can be concluded that the copolymerization of bioactive QAUDMAs with TEGDMA provided copolymers with high antibacterial activity and rewarding physicochemical properties.
继发龋的规模不断扩大，以及抗生素耐药菌株的出现，都要求开发具有抗菌性能的牙科复合材料。这可以通过将季铵基双甲基丙烯酸酯化学引入牙科复合材料来实现。在这项研究中，研究了由 60wt% 季铵基尿烷二甲基丙烯酸酯类似物（QAUDMA）和 40wt% 三乙二醇二甲基丙烯酸酯（TEGDMA）组成的 6 种新型共聚物的物理化学和抗菌性能。未固化的组合物具有合适的折射率（）、密度（）和玻璃化转变温度（）。共聚物具有低聚合收缩率（）、高转化率（）和高玻璃化转变温度（）。它们还表现出对 和 细菌菌株的高抗菌有效性。这表现为细胞增殖减少、黏附在其表面的细菌数量减少，以及存在生长抑制区。可以得出结论，将生物活性 QAUDMAs 与 TEGDMA 共聚，为共聚物提供了高抗菌活性和理想的物理化学性能。
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