Sales-Junior Reinaldo Adelino de, de Bessa Mariana Silva, Oliveira Francisca Jennifer Duarte de, Barbosa Bárbara Faria de Sá, Santos Kaiza de Sousa, Owen Michael, Feitosa Victor Pinheiro, Borges Boniek Castillo Dutra
Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Department of Operative Dentistry, College of Dentistry, University of Iowa, Iowa City, IA, United States.
Jpn Dent Sci Rev. 2025 Dec;61:112-137. doi: 10.1016/j.jdsr.2025.05.003. Epub 2025 Jun 4.
This scoping review aimed to collect, analyze, synthesize, and interpret the current data concerning antibacterial resin-based composites. The study followed the recommendations of the Joanna Briggs Institute and PRISMA Extension for Scoping Reviews. The searches were conducted in the PubMed, Embase, Web of Science, and Scopus databases. Studies evaluating efficacy, physical and chemical properties, cytotoxicity, and preventive effect against recurrent caries lesions provided by antibacterial resin-based composites published in the last 5 years and without language restriction were included. Fifty-three papers were analyzed. Only , and animal studies were published. The DMAHDM (dimethylaminohexadecyl methacrylate) was the most prevalent antibacterial agent in the resin composites and showed efficacy, did not increase cytotoxicity, nor jeopardize chemical and physical properties. The most used biofilm model and the test to evaluate the antibacterial effect was Streptococcus Mutans and the Colony Forming Unit Count. Antibacterial resin-based composites have performed exceedingly well in the large number of studies evaluated. However, clinical trials assessing the prevention of recurrent caries are absent and need to be further conducted to assure that using an antibacterial resin composite is a valid way to avoid restoration replacement due to recurrent caries.
本综述旨在收集、分析、综合并解读有关抗菌树脂基复合材料的现有数据。该研究遵循了乔安娜·布里格斯研究所和系统综述与Meta分析扩展版（PRISMA）关于综述的建议。检索在PubMed、Embase、科学网和Scopus数据库中进行。纳入了过去5年发表的、无语言限制的、评估抗菌树脂基复合材料的疗效、物理和化学性质、细胞毒性以及对复发性龋损的预防效果的研究。共分析了53篇论文。仅发表了体外研究和动物研究。二甲基氨基十六烷基甲基丙烯酸酯（DMAHDM）是树脂复合材料中最常见的抗菌剂，显示出有效性，未增加细胞毒性，也未损害化学和物理性质。最常用的生物膜模型和评估抗菌效果的测试是变形链球菌和菌落形成单位计数。在大量评估研究中，抗菌树脂基复合材料表现出色。然而，缺乏评估预防复发性龋的临床试验，需要进一步开展以确保使用抗菌树脂复合材料是避免因复发性龋而更换修复体的有效方法。
