苯环利定抑制体外记录的小鼠脑片含中脑多巴胺神经元的活性。
Phencyclidine suppresses the activity of midbrain dopamine-containing neurons recorded from mouse brain slices in vitro.
作者信息
Trulson M E, Arasteh K
出版信息
Eur J Pharmacol. 1987 Jan 20;133(3):345-9. doi: 10.1016/0014-2999(87)90032-x.
Phencyclidine produced a dose-dependent decrease in the activity of dopamine-containing neurons in the substantia nigra and ventral tegmental area recorded from mouse brain slices in vitro. The suppression of dopamine neuronal activity by phencyclidine was blocked by pretreatment of the animals with alpha-methyl-para-tyrosine or haloperidol. These data are in contrast with previous studies which reported that the activity of many midbrain dopamine neurons is increased by phencyclidine, while others are decreased and yet others showed no change.
苯环利定使体外记录的小鼠脑片中黑质和腹侧被盖区含多巴胺神经元的活性呈剂量依赖性降低。用α-甲基对酪氨酸或氟哌啶醇预处理动物可阻断苯环利定对多巴胺神经元活性的抑制。这些数据与之前的研究形成对比，之前的研究报道许多中脑多巴胺神经元的活性会因苯环利定而增加，而其他一些神经元的活性会降低，还有一些则没有变化。
Zotero 插件