Stepanova Mariia, Dubavik Aliaksei, Efimova Arina, Konovalova Mariya, Svirshchevskaya Elena, Zakharov Viktor, Orlova Anna
International Laboratory Hybrid Nanostructures for Biomedicine, ITMO University, Saint Petersburg 199034, Russia.
Department of Immunology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia.
Nanomaterials (Basel). 2022 Apr 19;12(9):1396. doi: 10.3390/nano12091396.
Multifunctional nanocomposites that combine both magnetic and photoluminescent (PL) properties provide significant advantages for nanomedical applications. In this work, a one-stage synthesis of magneto-luminescent nanocomposites (MLNC) with subsequent stabilization is proposed. Microwave synthesis of magnetic carbon dots (M-CDs) was carried out using precursors of carbon dots and magnetic nanoparticles. The effect of stabilization on the morphological and optical properties of nanocomposites has been evaluated. Both types of nanocomposites demonstrate magnetic and PL properties simultaneously. The resulting MLNCs demonstrated excellent solubility in water, tunable PL with a quantum yield of up to 28%, high photostability, and good cytocompatibility. Meanwhile, confocal fluorescence imaging showed that M-CDs were localized in the cell nuclei. Consequently, the multifunctional nanocomposites M-CDs are promising candidates for bioimaging and therapy.
兼具磁性和光致发光（PL）特性的多功能纳米复合材料为纳米医学应用带来了显著优势。在这项工作中，我们提出了一种磁光纳米复合材料（MLNC）的一步合成法及后续稳定化处理。利用碳点和磁性纳米粒子的前驱体通过微波合成法制备磁性碳点（M-CDs）。评估了稳定化处理对纳米复合材料形态和光学性质的影响。两种类型的纳米复合材料均同时展现出磁性和PL特性。所得的MLNCs在水中表现出优异的溶解性，可调谐PL，量子产率高达28%，具有高光稳定性和良好的细胞相容性。同时，共聚焦荧光成像显示M-CDs定位于细胞核中。因此，多功能纳米复合材料M-CDs有望成为生物成像和治疗的候选材料。
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