原发性甲状旁腺功能亢进症患者甲状旁腺腺瘤质量与骨转换生化指标的相关性

Correlation between mass of parathyroid adenoma and biochemical indicators of bone turnover in patients with primary hyperparathyroidism.

作者信息

Broulík P D, Stĕpán J J, Hradec E, Marek J, Pacovský V

出版信息

Exp Clin Endocrinol. 1986 Dec;88(3):360-4. doi: 10.1055/s-0029-1210618.

Abstract

We related the weight of the parathyroid adenoma to biochemical variables of bone turnover in 53 patients submitted to parathyroidectomy for primary hyperparathyroidism. There was a positive correlation (r = 0.61, p less than 0.01) between iPTH (c-assay) and adenoma weight. No correlations were found between either concentration of circulating iPTH or weight of parathyroid adenoma and severity of skeletal change expressed by total activity of serum alkaline phosphatase and its bone isoenzyme and urinary excretion of hydroxyproline. We conclude that the severity of bone changes in individual patients with primary hyperparathyroidism does not result from the direct tissue effect of a single hormone (parathyroid hormone).

摘要

我们将53例因原发性甲状旁腺功能亢进接受甲状旁腺切除术患者的甲状旁腺腺瘤重量与骨转换的生化指标进行了关联分析。免疫活性甲状旁腺激素（iPTH，化学发光法测定）与腺瘤重量之间存在正相关（r = 0.61，p < 0.01）。循环中iPTH浓度或甲状旁腺腺瘤重量与血清碱性磷酸酶及其骨同工酶总活性以及羟脯氨酸尿排泄所表达的骨骼变化严重程度之间均未发现相关性。我们得出结论，原发性甲状旁腺功能亢进个体患者的骨改变严重程度并非单一激素（甲状旁腺激素）的直接组织效应所致。