7T高分辨率快速成像磁共振波谱成像与氨基酸正电子发射断层扫描的比较：谷氨酰胺和甘氨酸作为脑肿瘤中有前景的生物标志物

7T HR FID-MRSI Compared to Amino Acid PET: Glutamine and Glycine as Promising Biomarkers in Brain Tumors.

作者信息

Hangel Gilbert, Lazen Philipp, Sharma Sukrit, Hristoska Barbara, Cadrien Cornelius, Furtner Julia, Rausch Ivo, Lipka Alexandra, Niess Eva, Hingerl Lukas, Motyka Stanislav, Gruber Stephan, Strasser Bernhard, Kiesel Barbara, Preusser Matthias, Roetzer-Pejrimovsky Thomas, Wöhrer Adelheid, Bogner Wolfgang, Widhalm Georg, Rössler Karl, Traub-Weidinger Tatjana, Trattnig Siegfried

机构信息

High-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.

Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.

出版信息

Cancers (Basel). 2022 Apr 26;14(9):2163. doi: 10.3390/cancers14092163.

DOI:10.3390/cancers14092163

PMID:35565293

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9101868/

Abstract

(1) Background: Recent developments in 7T magnetic resonance spectroscopic imaging (MRSI) made the acquisition of high-resolution metabolic images in clinically feasible measurement times possible. The amino acids glutamine (Gln) and glycine (Gly) were identified as potential neuro-oncological markers of importance. For the first time, we compared 7T MRSI to amino acid PET in a cohort of glioma patients. (2) Methods: In 24 patients, we co-registered 7T MRSI and routine PET and compared hotspot volumes of interest (VOI). We evaluated dice similarity coefficients (DSC), volume, center of intensity distance (CoI), median and threshold values for VOIs of PET and ratios of total choline (tCho), Gln, Gly, myo-inositol (Ins) to total N-acetylaspartate (tNAA) or total creatine (tCr). (3) Results: We found that Gln and Gly ratios generally resulted in a higher correspondence to PET than tCho. Using cutoffs of 1.6-times median values of a control region, DSCs to PET were 0.53 ± 0.36 for tCho/tNAA, 0.66 ± 0.40 for Gln/tNAA, 0.57 ± 0.36 for Gly/tNAA, and 0.38 ± 0.31 for Ins/tNAA. (4) Conclusions: Our 7T MRSI data corresponded better to PET than previous studies at lower fields. Our results for Gln and Gly highlight the importance of future research (e.g., using Gln PET tracers) into the role of both amino acids.

摘要

(1) 背景：7T磁共振波谱成像（MRSI）的最新进展使得在临床可行的测量时间内获取高分辨率代谢图像成为可能。已确定谷氨酰胺（Gln）和甘氨酸（Gly）这两种氨基酸为重要的潜在神经肿瘤标志物。我们首次在一组胶质瘤患者中比较了7T MRSI与氨基酸PET。(2) 方法：在24例患者中，我们对7T MRSI和常规PET进行了配准，并比较了感兴趣热点体积（VOI）。我们评估了PET的VOI的骰子相似系数（DSC）、体积、强度中心距离（CoI）、中位数和阈值，以及总胆碱（tCho）、Gln、Gly、肌醇（Ins）与总N-乙酰天门冬氨酸（tNAA）或总肌酸（tCr）的比率。(3) 结果：我们发现，Gln和Gly比率与PET的对应性通常高于tCho。使用对照区域中位数1.6倍的截断值，tCho/tNAA与PET的DSC为0.53±0.36，Gln/tNAA为0.66±0.40，Gly/tNAA为0.57±0.36，Ins/tNAA为0.38±0.31。(4) 结论：我们的7T MRSI数据比之前在低场强下的研究与PET的对应性更好。我们关于Gln和Gly的结果突出了未来研究（例如，使用Gln PET示踪剂）探究这两种氨基酸作用的重要性。