[The serotoninergic component in the mechanism of the development of neurogenic damage to the stomach].

The involvement of the serotoninergic system in the development of neurogenic gastric lesions induced by the three-hour electrical stimulation of the immobilized rats was shown. Serotonin (0.4 mg/kg) and d,1-5-hydroxytryptophan (50 mg/kg) failed to prevent the development of neurogenic gastric lesions. Deseril (0.5 mg/kg) and BC-105 (1 mg/kg) significantly decreased the formation of hemorrhagic erosions and prevented a decrease of serotonin and norepinephrine levels as well as creatine phosphate content in the stomach tissue.