Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Department of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.
Nutrients. 2022 Apr 19;14(9):1685. doi: 10.3390/nu14091685.
Evidence of dried plum's benefits on bone continues to emerge. This study investigated the contribution of the fruit's polyphenol (PP) and carbohydrate (CHO) components on a bone model of postmenopausal osteoporosis to explore their prebiotic activity. Osteopenic ovariectomized mice were fed diets supplemented with dried plum, a crude extract of dried plum's polyphenolic compounds, or the PP or CHO fraction of the crude extract. The effects of treatments on the bone phenotype were assessed at 5 and 10 weeks as well as the prebiotic activity of the different components of dried plum. Both the CHO and PP fractions of the extract contributed to the effects on bone with the CHO suppressing bone formation and resorption, and the PP temporally down-regulating formation. The PP and CHO components also altered the gut microbiota and cecal short chain fatty acids. These findings demonstrate that the CHO as well as the PP components of dried plum have potential prebiotic activity, but they have differential roles in mediating the alterations in bone formation and resorption that protect bone in estrogen deficiency.
关于李子干对骨骼益处的证据不断涌现。本研究调查了水果中的多酚（PP）和碳水化合物（CHO）成分对绝经后骨质疏松症骨骼模型的贡献，以探索其益生元活性。骨质疏松症去卵巢小鼠喂食添加李子干、李子干多酚化合物粗提取物或粗提取物的 PP 或 CHO 部分的饮食。在 5 周和 10 周时评估治疗对骨骼表型的影响，以及李子干不同成分的益生元活性。提取物的 CHO 和 PP 部分均对骨骼产生影响，CHO 抑制骨形成和吸收，而 PP 暂时下调形成。PP 和 CHO 成分还改变了肠道微生物群和盲肠短链脂肪酸。这些发现表明，李子干的 CHO 和 PP 成分具有潜在的益生元活性，但它们在调节骨形成和吸收的改变方面发挥着不同的作用，从而保护雌激素缺乏时的骨骼。
