硝基吲哚啉笼状钙离子螯合剂的合成与光解评估。
Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators.
机构信息
Chemical Biology STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
出版信息
Molecules. 2022 Apr 20;27(9):2645. doi: 10.3390/molecules27092645.
Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.
经光不稳定的硝基吲哚啉基团衍生的羧基化神经活性氨基酸是在生理溶液中实现亚微秒级神经活性氨基酸释放的高效试剂。然而，对于钙离子螯合剂则并非如此。在这项研究中，发现硝基吲哚啉笼状 BAPTA 完全光稳定，而只有当被钙离子饱和时，硝基吲哚啉笼状 EDTA 才会发生光解。
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