Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia.
Molecules. 2022 Apr 21;27(9):2665. doi: 10.3390/molecules27092665.
Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy modes employed, including chemotherapy and radiotherapy, have been reported to be significant in cancer management, but the side effects associated with these treatment strategies are still a health problem. Therefore, alternative anticancer drugs based on medicinal plants or their active compounds have been generating attention because of their less serious side effects. Medicinal plants are an excellent source of phytochemicals that have been recognized to have health-prompting effects through modulating cell signaling pathways. Resveratrol is a well-known polyphenolic molecule with antioxidant, anti-inflammatory, and health-prompting effects among which its anticancer role has been best defined. Additionally, this polyphenol has confirmed its role in cancer management because it activates tumor suppressor genes, suppresses cell proliferation, induces apoptosis, inhibits angiogenesis, and modulates several other cell signaling molecules. The anticancer potential of resveratrol is recognized in numerous in vivo and in vitro studies. Previous experimental data suggested that resveratrol may be valuable in cancer management or improve the efficacy of drugs when given with anticancer drugs. This review emphasizes the potential role of resveratrol as an anticancer drug by modulating numerous cells signaling pathways in different types of cancer.
癌症是全球主要的死亡原因之一。已报道多种癌症治疗模式，包括化疗和放疗，在癌症治疗中具有重要作用，但这些治疗策略相关的副作用仍然是一个健康问题。因此，基于药用植物或其活性化合物的替代抗癌药物因其副作用较小而受到关注。药用植物是植物化学物质的极好来源，这些物质已被证明通过调节细胞信号通路具有促进健康的作用。白藜芦醇是一种众所周知的多酚分子，具有抗氧化、抗炎和促进健康的作用，其中其抗癌作用已得到最好的定义。此外，这种多酚已被证实其在癌症管理中的作用，因为它可以激活肿瘤抑制基因、抑制细胞增殖、诱导细胞凋亡、抑制血管生成，并调节几种其他细胞信号分子。白藜芦醇在许多体内和体外研究中都表现出了抗癌潜力。先前的实验数据表明，白藜芦醇与抗癌药物联合使用时，可能对癌症治疗或提高药物疗效有价值。本综述强调了白藜芦醇通过调节不同类型癌症中多种细胞信号通路作为抗癌药物的潜在作用。
