基于过饱和的药物传递系统：提高难溶性药物生物利用度的策略。

Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs.

机构信息

Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.

Faculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, Romania.

出版信息

Molecules. 2022 May 6;27(9):2969. doi: 10.3390/molecules27092969.

DOI:10.3390/molecules27092969

PMID:35566319

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9101434/

Abstract

At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions, nanoparticles, liposomes, etc.), salt formation, and many more. One promising avenue attaining attention presently is supersaturated drug delivery systems. When exposed to gastrointestinal fluids, drug concentration exceeds equilibrium solubility and a supersaturation state is maintained long enough to be absorbed, enhancing bioavailability. In this review, the latest developments in supersaturated drug delivery systems are addressed in depth.

摘要

目前，大多数合成的 API 仍然是制剂开发的难题。许多技术被用于或探索用于提高溶解度，例如化学修饰、新型药物传递系统（微乳液、纳米粒、脂质体等）、盐形成等。目前受到关注的一个有前途的途径是过饱和药物传递系统。当暴露于胃肠液中时，药物浓度超过平衡溶解度，并且保持过饱和状态足够长的时间以被吸收，从而提高生物利用度。在这篇综述中，深入探讨了过饱和药物传递系统的最新进展。