Synthesis, X-ray Structure and Biological Studies of New Self-Assembled Cu(II) Complexes Derived from -Triazine Schiff Base Ligand.

The two ligands 2-(1-(2-(4,6-dimorpholino-1,3,5-triazin-2-yl)hydrazono)ethyl)aniline () and 2-(1-(2-(4,6-dimorpholino-1,3,5-triazin-2-yl)hydrazono)ethyl)phenol () were used to synthesize three heteroleptic Cu(II) complexes via a self-assembly technique. The structure of the newly synthesized complexes was characterized using elemental analysis, FTIR and X-ray photoelectron spectroscopy (XPS) to be [Cu(DMAT)(HO)(NO)]NO.CHOH (), [Cu(DMOT)(CHCOO)] () and [Cu(DMOT)(NO)] (). X-ray single-crystal structure of complex revealed a hexa-coordinated Cu(II) ion with one as a neutral tridentate -chelate, one bidentate nitrate group and one water molecule. In the case of complex , the Cu(II) is tetra-coordinated with one as an anionic tridentate -chelate and one monodentate acetate group. The antimicrobial, antioxidant and anticancer activities of the studied compounds were examined. Complex had the best anticancer activity against the lung carcinoma A-549 cell line (IC = 5.94 ± 0.58 µM) when compared to -platin (25.01 ±2.29 µM). The selectivity index (SI) of complex was the highest (6.34) when compared with the free ligands (1.3-1.8), and complexes (0.72) and (2.97). The results suggested that, among those compounds studied, complex is the most promising anticancer agent against the lung carcinoma A-549 cell line. In addition, complex had the highest antioxidant activity (IC = 13.34 ± 0.58 µg/mL) which was found to be comparable to the standard ascorbic acid (IC = 10.62 ± 0.84 µg/mL). Additionally, complex showedbroad-spectrum antimicrobial action against the microbes studied. The results revealed it to possess the strongest action of all the three complexes against . The MIC values found are 39.06, 39.06 and 78.125 μg/mL for complexes -, respectively.