Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt.
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Molecules. 2022 May 6;27(9):2989. doi: 10.3390/molecules27092989.
The two ligands 2-(1-(2-(4,6-dimorpholino-1,3,5-triazin-2-yl)hydrazono)ethyl)aniline () and 2-(1-(2-(4,6-dimorpholino-1,3,5-triazin-2-yl)hydrazono)ethyl)phenol () were used to synthesize three heteroleptic Cu(II) complexes via a self-assembly technique. The structure of the newly synthesized complexes was characterized using elemental analysis, FTIR and X-ray photoelectron spectroscopy (XPS) to be [Cu(DMAT)(HO)(NO)]NO.CHOH (), [Cu(DMOT)(CHCOO)] () and [Cu(DMOT)(NO)] (). X-ray single-crystal structure of complex revealed a hexa-coordinated Cu(II) ion with one as a neutral tridentate -chelate, one bidentate nitrate group and one water molecule. In the case of complex , the Cu(II) is tetra-coordinated with one as an anionic tridentate -chelate and one monodentate acetate group. The antimicrobial, antioxidant and anticancer activities of the studied compounds were examined. Complex had the best anticancer activity against the lung carcinoma A-549 cell line (IC = 5.94 ± 0.58 µM) when compared to -platin (25.01 ±2.29 µM). The selectivity index (SI) of complex was the highest (6.34) when compared with the free ligands (1.3-1.8), and complexes (0.72) and (2.97). The results suggested that, among those compounds studied, complex is the most promising anticancer agent against the lung carcinoma A-549 cell line. In addition, complex had the highest antioxidant activity (IC = 13.34 ± 0.58 µg/mL) which was found to be comparable to the standard ascorbic acid (IC = 10.62 ± 0.84 µg/mL). Additionally, complex showedbroad-spectrum antimicrobial action against the microbes studied. The results revealed it to possess the strongest action of all the three complexes against . The MIC values found are 39.06, 39.06 and 78.125 μg/mL for complexes -, respectively.
两种配体 2-(1-(2-(4,6-二吗啉基-1,3,5-三嗪-2-基)腙基)乙基)苯胺 () 和 2-(1-(2-(4,6-二吗啉基-1,3,5-三嗪-2-基)腙基)乙基)苯酚 () 被用于通过自组装技术合成三种异核 Cu(II) 配合物。新合成的配合物的结构通过元素分析、傅里叶变换红外光谱 (FTIR) 和 X 射线光电子能谱 (XPS) 进行了表征，确定为 [Cu(DMAT)(HO)(NO)]NO.CHOH ()、[Cu(DMOT)(CHCOO)] () 和 [Cu(DMOT)(NO)] ()。配合物的 X 射线单晶结构表明，Cu(II) 离子具有六配位，一个 作为中性三齿螯合配体，一个双齿硝酸盐基团和一个水分子。对于配合物 ，Cu(II) 是四配位的，一个 作为阴离子三齿螯合配体和一个单齿乙酸根基团。研究了这些化合物的抗菌、抗氧化和抗癌活性。与顺铂（25.01 ±2.29 µM）相比，配合物 对肺癌 A-549 细胞系的抗癌活性最佳（IC = 5.94 ± 0.58 µM）。与游离配体（1.3-1.8）、配合物 （0.72）和 （2.97）相比，配合物 的选择性指数（SI）最高（6.34）。结果表明，在所研究的化合物中，配合物 是最有前途的肺癌 A-549 细胞系抗癌药物。此外，配合物 具有最高的抗氧化活性（IC = 13.34 ± 0.58 µg/mL），与标准抗坏血酸（IC = 10.62 ± 0.84 µg/mL）相当。此外，配合物 对所研究的微生物表现出广谱的抗菌作用。结果表明，它对 具有三种配合物中最强的作用。发现配合物的 MIC 值分别为 39.06、39.06 和 78.125 μg/mL。
