Kim Jong-Heon, Lee Hyejin, Oh Junho, Suk Kyoungho, Chun Bo Young
Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
J Clin Med. 2022 May 7;11(9):2635. doi: 10.3390/jcm11092635.
This study aimed to evaluate the correlation between plasma lipocalin-2 (LCN2) levels and myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) seropositivity in patients with optic neuritis. Peripheral blood samples were collected from 19 patients with optic neuritis and 20 healthy controls. Plasma LCN2 and MOG-IgG levels were measured using enzyme-linked immunosorbent assay and a cell-based assay, respectively. The correlation between plasma LCN2 levels and MOG-IgG titers in patients with optic neuritis was analyzed. Receiver operating characteristic (ROC) curves were constructed to assess and compare the ability of plasma LCN2 and MOG-IgG levels for predicting optic neuritis recurrence. Patients with MOG-IgG-positive optic neuritis had significantly higher mean plasma LCN2 levels than controls and patients with MOG-IgG-negative optic neuritis ( = 0.037). Plasma LCN2 and MOG-IgG levels were significantly correlated in patients with optic neuritis ( = 0.553, = 0.0141). There were no significant differences in the areas under the ROC curve (AUC) of plasma LCN2 (0.693, 95% confidence interval [CI] 0.443-0.880, = 0.133) and MOG-IgG (0.641, 95% CI, 0.400-0.840, = 0.298) levels (95% CI, -0.266-0.448, = 0.618). Plasma LCN2 levels may aid differentiation of MOG-IgG-positive optic neuritis from MOG-IgG-negative optic neuritis.
本研究旨在评估视神经炎患者血浆脂质运载蛋白-2（LCN2）水平与髓鞘少突胶质细胞糖蛋白（MOG）-免疫球蛋白G（IgG）血清阳性之间的相关性。收集了19例视神经炎患者和20名健康对照者的外周血样本。分别采用酶联免疫吸附测定法和基于细胞的测定法检测血浆LCN2和MOG-IgG水平。分析了视神经炎患者血浆LCN2水平与MOG-IgG滴度之间的相关性。构建受试者工作特征（ROC）曲线，以评估和比较血浆LCN2和MOG-IgG水平预测视神经炎复发的能力。MOG-IgG阳性的视神经炎患者的平均血浆LCN2水平显著高于对照组和MOG-IgG阴性的视神经炎患者（P = 0.037）。视神经炎患者血浆LCN2和MOG-IgG水平显著相关（r = 0.553，P = 0.0141）。血浆LCN2（曲线下面积[AUC]为0.693，95%置信区间[CI]为0.443 - 0.880，P = 0.133）和MOG-IgG（AUC为0.641，95% CI为0.400 - 0.840，P = 0.298）水平的ROC曲线下面积无显著差异（95% CI为 - 0.266 - 0.448，P = 0.618）。血浆LCN2水平可能有助于鉴别MOG-IgG阳性的视神经炎与MOG-IgG阴性的视神经炎。
