Spirito Lorenzo, Morelli Michele, La Rocca Roberto, Napolitano Luigi, Ruvolo Claudia Collà, Romano Lorenzo, di Giovanni Angelo, Sciorio Carmine, Concetti Sergio, Montanari Emanuele, Tripodi Francesca, Fusco Ferdinando, Capece Marco
Department of Neurosciences, Reproductive Sciences, and Odontostomatology, University of Naples "Federico II", 80131 Naples, Italy.
Department of Urology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
J Clin Med. 2022 May 8;11(9):2645. doi: 10.3390/jcm11092645.
We performed a monocentric longitudinal study on sexually active male patients, from May 2021 to October 2021, with SARS-CoV-2 infection confirmed with a nasopharyngeal reverse transcriptase polymerase chain reaction (RT-PCR). The questionnaires were delivered by email. The study period was divided into the periods before getting tested (T1), during quarantine (T2), 1 month after a negative test (T3), and 3 months after a negative test (T4). All participants were invited to complete these questionnaires: 10- and 6-item questionnaires, a sexual distress schedule (SDS), and the international index of erectile function questionnaire of 15 items (IIEF-15). The primary endpoint was to evaluate the impact of quarantine on male sexual function (SF) during and after the SARS-CoV-2 infection. A total of 22 male patients met the inclusion criteria. The differences for both SDS and IIEF-15 scores, between T1−T2 (27 (IQR 24.0−32.2) vs. 37.5 (IQR 34.2−45.5), 45 (IQR 38.0−50.2) vs. 28.5 (IQR 19.5−38.0)), T2−T3 (37.5 (IQR 34.2−45.5) vs. 28 (IQR 24.0−31.0), and 28.5 (IQR 19.5−38.0) vs. 39.5 (IQR 35.5−44.2)) were statistically significant (p < 0.001), respectively. Moreover, between T1−T4, no statistically significant difference (p > 0.05) was recorded in both SDS (27 (IQR 24.0−32.2) vs. 26.5 (IQR 24−30.2)) and IIEF-15 (45 (IQR 38.0−50.2) vs. 28.5 (IQR 19.5−38.0)). In 20 patients (90.9%), SARS-CoV-2 had a huge impact on relationship and sexual life, but no patient attended a clinic for sexual difficulties. In conclusion quarantine has negatively influenced SF in infected patients; however, 3 months after the rRT-PCR negative test, a promising return to the preinfection SF values is observed.
2021年5月至2021年10月，我们对有性活动的男性患者进行了一项单中心纵向研究，这些患者经鼻咽逆转录酶聚合酶链反应（RT-PCR）确诊感染了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。问卷通过电子邮件发送。研究期分为检测前（T1）、隔离期间（T2）、检测结果为阴性后1个月（T3）和检测结果为阴性后3个月（T4）。邀请所有参与者完成以下问卷：10项和6项问卷、性困扰量表（SDS）以及15项勃起功能国际指数问卷（IIEF-15）。主要终点是评估隔离对SARS-CoV-2感染期间及之后男性性功能（SF）的影响。共有22名男性患者符合纳入标准。SDS和IIEF-15评分在T1−T2（27（四分位距24.0−32.2）对37.5（四分位距34.2−45.5），45（四分位距38.0−50.2）对28.5（四分位距19.5−38.0））、T2−T3（37.5（四分位距34.2−45.5）对（28（四分位距24.0−31.0））以及28.5（四分位距19.5−38.0）对39.5（四分位距35.5−44.2））之间的差异均具有统计学意义（p<0.001）。此外，在T1−T4之间，SDS（27（四分位距24.0−-32.2）对26.5（四分位距24−30.2））和IIEF-15（45（四分位距38.0−50.2）对28.5（四分位距19.5−38.0））均未记录到统计学显著差异（p>0.05）。在20名患者（90.9%）中，SARS-CoV-2对人际关系和性生活产生了巨大影响，但没有患者因性方面的困难前往诊所就诊。总之，隔离对感染患者的性功能产生了负面影响；然而，在逆转录酶聚合酶链反应（rRT-PCR）检测结果为阴性3个月后，观察到有望恢复到感染前的性功能值。
