Hosseini Abdolkarim, Badri Taleb, Esmaeili Gouvarchin Ghaleh Hadi, Hassanpour Kazem, Alishiri Gholamhossein, Akbariqomi Mostafa, Farnoosh Gholamreza
Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Fundam Clin Pharmacol. 2022 Dec;36(6):918-929. doi: 10.1111/fcp.12805. Epub 2022 May 31.
The coronavirus disease 2019 (COVID-19) pandemic has been going on around the world for more than a year and has cost a lot, as well as affected the quality of life of many. The psychological stress like delirium and sleep disturbances caused by the COVID-19 has affected many people in direct or indirect way by the disease. Insomnia and sleep deprivation have a negative effect on the immune system as well as disorders of the hormonal system, including the production and secretion of melatonin, known as the sleep hormone. Melatonin is a known anti-inflammatory and antioxidant agent in addition to its role in regulating circadian rhythms. In this review, we investigated the relationship between the effect of psychological stress caused by COVID-19 on patients, their families, health care workers, and occupations as well as how melatonin might act as a prophylactic agent with sedative effects and sleep enhancement potential. Search terms "melatonin" and "COVID-19" were manually searched on PubMed or other electronic database and relevant articles were included. Based on the review of scholarly articles, it can be inferred that melatonin, as an endogenous hormone controlling and regulating sleep and wakefulness in various researches, has a good potential due to its antioxidant and anti-inflammatory with minimal side effects. These beneficial effects highlight the impact of melatonin as an adjuvant and a potential alternative for the better management of SARS-CoV-2 infection in high-risk populations.
2019冠状病毒病（COVID-19）大流行在全球已持续一年多，造成了巨大损失，也影响了许多人的生活质量。COVID-19引发的诸如谵妄和睡眠障碍等心理压力，以直接或间接的方式影响了许多人。失眠和睡眠剥夺对免疫系统以及激素系统紊乱有负面影响，包括被称为睡眠激素的褪黑素的产生和分泌。褪黑素除了在调节昼夜节律方面发挥作用外，还是一种已知的抗炎和抗氧化剂。在本综述中，我们研究了COVID-19引发的心理压力对患者、其家人、医护人员和职业的影响之间的关系，以及褪黑素如何作为一种具有镇静作用和改善睡眠潜力的预防剂发挥作用。在PubMed或其他电子数据库中手动搜索了“褪黑素”和“COVID-19”等检索词，并纳入了相关文章。基于对学术文章的综述，可以推断，褪黑素作为一种在各种研究中控制和调节睡眠与觉醒的内源性激素，因其抗氧化和抗炎作用且副作用极小而具有良好的潜力。这些有益作用凸显了褪黑素作为辅助剂以及在高危人群中更好地管理SARS-CoV-2感染的潜在替代方案的影响。
