Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India.
Department of Chemistry, Sri Venketeswara College, University of Delhi, New Delhi, India.
Arch Pharm (Weinheim). 2022 Aug;355(8):e2200084. doi: 10.1002/ardp.202200084. Epub 2022 May 13.
The conceptual layout of monoamine oxidase (MAO) inhibitors has been modified to explore their potential biological application in the case of neurological disorders for the time being. The current review article is an effort to display the summation of innovative conceptual prospects of MAO inhibitors and their intriguing chemistry and bioactivity. Based on this scenario, we emphasize the pivotal role of the benzyloxy moiety attached to scaffolds like oxadiazolones, indolalkylamines, safinamide, caffeine, benzofurans, α-tetralones, β-nitrostyrene, benzoquinones, coumarins, indoles, chromones, and chromanone analogs, while acting as an MAO inhibitor.
目前，人们一直在探索单胺氧化酶（MAO）抑制剂在神经紊乱疾病方面的潜在生物学应用，对其的概念性设计也进行了相应的修改。本文旨在综述 MAO 抑制剂的创新概念性前景及其有趣的化学和生物活性。基于这一背景，我们强调了连在苯氧基亚乙基部分的重要作用，该部分连在一些支架上，比如噁二唑酮、吲哚烷胺、沙芬酰胺、咖啡因、苯并呋喃、α-四氢萘酮、β-硝基苯乙烯、苯醌、香豆素、吲哚、色酮和色烷酮类似物，同时它也作为 MAO 抑制剂。
