School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P. R. China.
Chem Biodivers. 2022 Jun;19(6):e202200208. doi: 10.1002/cbdv.202200208. Epub 2022 Jun 1.
γ-Aromatic butenolides (γ-AB) are an important type of structures found in many bioactive microbial secondary metabolites (SMs). γ-AB refer to a group of natural products (NPs) containing five-membered (unsaturated) lactones with 3-phenyl and 4-benzyl substituents. Their wide-range biological activities have inspired pharmaceutical chemists to explore its biosynthesis mechanisms and design strategies to construct the γ-AB skeleton. Recently, there are a great deal of interesting research progress on the structures, biological activities and biosynthesis of γ-AB. This review will focus on these aspects and summarize the important achievements of γ-AB from 1975 to 2021.
γ-芳香丁烯内酯（γ-AB）是许多生物活性微生物次生代谢产物（SMs）中存在的一种重要结构类型。γ-AB 是指一类含有 3-苯基和 4-苄基取代基的五元（不饱和）内酯的天然产物（NPs）。其广泛的生物活性激发了药物化学家探索其生物合成机制和设计策略来构建 γ-AB 骨架。最近，γ-AB 的结构、生物活性和生物合成方面有大量有趣的研究进展。本综述将重点关注这些方面，并总结 1975 年至 2021 年 γ-AB 的重要研究成果。
