Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Mar Drugs. 2017 Nov 14;15(11):359. doi: 10.3390/md15110359.
The marine-derived fungus isolated from the Mediterranean sponge and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (-), seven (3)-resorcylide derivatives (-), two butenolide-resorcylide dimers ( and ), and three dihydroisocoumarins (-). Among them, fourteen compounds (-, -) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry). TDDFT-ECD (Time-Dependent Density Functional Theory-Electronic Circular Dichroism) calculations were performed to determine the absolute configurations of chiral compounds. The butenolide-resorcylide dimers talarodilactones A and B ( and ) exhibited potent cytotoxicity against the L5178Y murine lymphoma cell line with IC values of 3.9 and 1.3 µM, respectively.
从地中海海绵中分离出来的海洋真菌，在固体大米培养基上培养，得到了十七种内酯衍生物，包括五种丁烯内酯（-）、七种（3）-resorcylide 衍生物（-）、两种丁烯内酯-resorcylide 二聚体（和）和三种二氢异香豆素（-）。其中，十四种化合物（-）是新的天然产物。通过 1D 和 2D NMR（核磁共振）光谱以及 ESI-HRMS（电喷雾电离-高分辨率质谱）确定了分离化合物的结构。通过 TDDFT-ECD（时间相关密度泛函理论-电子圆二色性）计算确定了手性化合物的绝对构型。丁烯内酯-resorcylide 二聚体 talarodilactones A 和 B（和）对 L5178Y 小鼠淋巴瘤细胞系表现出强烈的细胞毒性，IC 值分别为 3.9 和 1.3 μM。
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