Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer/World Health Organisation, Lyon, France.
Department of Obstetrics and Gynaecology, Kamenge University Hospital, Burundi University, Bujumbura, Burundi.
Int J Cancer. 2022 Oct 1;151(7):1120-1126. doi: 10.1002/ijc.34117. Epub 2022 Jun 3.
This longitudinal study aimed at evaluating the effectiveness, acceptability and safety of the thermal ablation procedure (TA) in the treatment of cervical neoplasia. Women referred to the Gynaecology ward for symptoms or for opportunistic screening were assessed by visual inspection with acetic acid (VIA) and colposcopy. Those with lesions eligible to ablation were counselled and treated by TA. They were inquired about the level of pain during the procedure, and their level of satisfaction. Patients were followed up at 6 weeks for any complication and reassessed by VIA and colposcopy at 12 months for any persistent or recurrent lesion and for any adverse event. A total of 86 women with a positive VIA test were included in the study. The mean age was 46 years (28-61 years). Most of the women did not complain about any adverse event during treatment; one-third presented mild pain or cramp. At the 6-week visit, watery discharge was the main adverse event reported. All women were highly satisfied with TA and most of them would recommend it. At the 12-month visit, 82 women were examined (95% follow-up rate), and the overall cure rate was 96% (low-grade lesions: 98%; high-grade lesions: 94%). Three women presented low- and high-grade lesions that were treated by TA. No major adverse event or hospitalisation after the treatment was reported. In conclusion, TA was an effective procedure with a high cure rate at the 1-year follow-up visit. It was acceptable and safe, with only minor short-term side-effects reported and with a high satisfaction rate among the patients.
这项纵向研究旨在评估热消融治疗（TA）在治疗宫颈病变中的有效性、可接受性和安全性。妇科病房的女性因症状或机会性筛查接受醋酸视觉检查（VIA）和阴道镜检查。对符合消融条件的病变进行咨询并进行 TA 治疗。询问患者在治疗过程中的疼痛程度及其满意度。患者在 6 周时接受任何并发症的随访，并在 12 个月时通过 VIA 和阴道镜检查评估任何持续或复发的病变和任何不良事件。共有 86 名 VIA 检测阳性的女性纳入研究。平均年龄为 46 岁（28-61 岁）。大多数女性在治疗过程中没有报告任何不良事件；三分之一的女性出现轻度疼痛或痉挛。在 6 周时，水样分泌物是主要的不良事件。所有女性对 TA 非常满意，大多数女性会推荐 TA。在 12 个月时，82 名女性接受了检查（随访率 95%），总治愈率为 96%（低级别病变：98%；高级别病变：94%）。三名女性出现低级别和高级别病变，均接受 TA 治疗。治疗后无重大不良事件或住院。总之，TA 是一种有效的治疗方法，在 1 年随访时治愈率高。它具有良好的可接受性和安全性，仅报告有轻微的短期副作用，患者满意度高。
