Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; R&D, Drug Product Development, Hovione FarmaCiencia SA, Lisbon, Portugal.
Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research, Coimbra, Portugal.
Eur J Pharm Biopharm. 2022 Jul;176:1-20. doi: 10.1016/j.ejpb.2022.05.002. Epub 2022 May 11.
Powders for nasal delivery have been recognized as advantageous dosage forms over liquids due to increased stability and residence time on nasal mucosa, with improved bioavailability. They can be manufactured by spray-drying, allowing the optimization of the particle properties that are critical to guarantee nasal deposition, as size and shape. It is also a scalable and flexible method already explored extensively in the pharmaceutical industry. However, it is important to understand how process parameters, particle physical properties and formulation considerations affect the product performance. Hence, this review aims to provide an overview of nasal powder formulation and processing through spray drying, with an emphasis on the variables that impact on performance. To this purpose, we describe the physical, biological and pharmacological phenomena prior to drug absorption as well as the most relevant powder properties. Formulation considerations including qualitative and quantitative composition are then reviewed, as well as manufacturing considerations including spray drying relevant parameters.
鼻腔给药粉末因其在鼻腔黏膜上的稳定性和停留时间增加，生物利用度提高，已被认为是优于液体的剂型。它们可以通过喷雾干燥来制造，从而可以优化对保证鼻腔沉积至关重要的颗粒特性，如大小和形状。这也是一种已经在制药行业广泛探索的可扩展和灵活的方法。然而，重要的是要了解工艺参数、颗粒物理性质和配方考虑因素如何影响产品性能。因此，本综述旨在通过喷雾干燥概述鼻腔粉末制剂和加工，重点介绍影响性能的变量。为此，我们描述了药物吸收前的物理、生物和药理学现象以及最相关的粉末特性。然后回顾了配方考虑因素，包括定性和定量组成，以及包括喷雾干燥相关参数在内的制造考虑因素。
