School of Nursing and Midwifery, Edith Cowan University, Joondalup, Perth, Australia.
School of Science, Edith Cowan University, Perth, Western Australia, Australia.
BMJ Open. 2022 May 13;12(5):e056929. doi: 10.1136/bmjopen-2021-056929.
Human immunodeficiency virus (HIV) prevention interventions focused at reducing risky sexual behaviours are an important strategy for preventing HIV infection among youth (15-24 years) who continue to be vulnerable to the disease. This systematic review aims to synthesise current global evidence on the effectiveness of HIV prevention interventions for reducing risky sexual behaviour among youth in the last decade.
MEDLINE/PubMed, EMBASE, PsychINFO, ProQuest Central, CINAHL and Web of Science databases, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform and reference lists of included studies and systematic reviews on effectiveness of HIV prevention interventions for reducing risky sexual behaviour among youth will be searched for articles published from August 2011 to August 2021. Eligible studies will be longitudinal studies including randomised controlled trials and quasi-experimental studies that examined the effectiveness of HIV prevention interventions among youth populations (15-24 years) with risky sexual behaviour as a primary or secondary outcome. Study selection and quality assessment will be undertaken independently by three reviewers and disagreements will be resolved through consensus. Data analysis will be undertaken using RevMan software V.5.3.3. A random effects meta-analysis will be conducted to report heterogeneous data where statistical pooling is achievable. We will use I statistics to test for heterogeneity. Where appropriate, a funnel plot will be generated to assess publication bias. Where statistical pooling is unachievable, the findings will be reported in a narrative form, together with tables and figures to assist in data presentation if required. Reporting of the systematic review will be informed by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Ethical approval is not required. Findings of the systematic review will be published in a peer-reviewed journal. The findings will be of interest to researchers, healthcare practitioners and policymakers.
CRD42021271774.
以减少危险性行为为重点的人类免疫缺陷病毒 (HIV) 预防干预措施是预防青年（15-24 岁）感染艾滋病毒的重要策略，他们仍然容易受到该疾病的影响。本系统评价旨在综合过去十年中全球关于减少青年危险性行为的 HIV 预防干预措施有效性的现有证据。
将检索 MEDLINE/PubMed、EMBASE、PsychINFO、ProQuest Central、CINAHL 和 Web of Science 数据库、ClinicalTrials.gov 和世界卫生组织国际临床试验注册平台以及关于减少青年危险性行为的 HIV 预防干预措施有效性的系统评价的参考文献列表，以获取 2011 年 8 月至 2021 年 8 月期间发表的文章。合格的研究将是纵向研究，包括随机对照试验和准实验研究，这些研究检查了 HIV 预防干预措施对有危险性行为的青年人群（15-24 岁）的有效性，将危险性行为作为主要或次要结局。研究选择和质量评估将由三名评审员独立进行，如果存在分歧，将通过协商解决。数据分析将使用 RevMan 软件 V.5.3.3 进行。如果可以进行统计汇总，将进行随机效应荟萃分析以报告异质性数据。我们将使用 I 统计量来检验异质性。在适当的情况下，将生成漏斗图以评估发表偏倚。如果无法进行统计汇总，将以叙述形式报告研究结果，并根据需要使用表格和图形协助数据呈现。系统评价的报告将遵循系统评价和荟萃分析的首选报告项目 (PRISMA) 指南。
不需要伦理批准。系统评价的结果将发表在同行评议的期刊上。研究结果将引起研究人员、医疗保健从业者和政策制定者的兴趣。
PROSPERO 注册号：CRD42021271774。
