Du Jun, Jin Guifang, Zhang Hongbo, Don Operario, Shi Haiyan, Wang Sainan, Wang Jun, Sun Yehuan, Zhang Zhihua
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, China.
Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.
Curr HIV/AIDS Rep. 2025 Mar 18;22(1):25. doi: 10.1007/s11904-025-00733-4.
Digital health interventions have demonstrated great potential to advance HIV prevention and care. However, their effectiveness in improving the pre-exposure prophylaxis (PrEP) care continuum has not yet been validated. This systematic review aimed to evaluate the effectiveness of digital health interventions in enhancing the PrEP care continuum among men who have sex with men (MSM) populations.
Following PRISMA guidelines, a comprehensive search was conducted across four databases-PubMed, Web of Science, Embase, and Cochrane Library-to identify randomized controlled trials (RCTs) published before July 2, 2024. Out of the 3,539 records initially identified, 12 RCTs met the inclusion criteria. The majority of the studies were conducted in the United States (10/12, 83.3%), with the remaining 2 studies conducted in China. Participant ages ranged from 18 to 65 years. The studies employed various digital health tools, including mobile apps, text message, and social media platforms. While digital health interventions were found to be feasible and acceptable, only a few studies demonstrated statistically significant increases in PrEP utilization and adherence. Digital health interventions have demonstrated potential to enhance the PrEP care continuum in MSM populations. Future research should focus on large-scale, multicenter trials that combine digital tools with personalized, culturally sensitive strategies to improve PrEP uptake and adherence. Integrating big data, artificial intelligence (AI), and non-digital approaches like community outreach and psychosocial support could further strengthen the effectiveness of these interventions.
数字健康干预措施已显示出在推进艾滋病预防和治疗方面的巨大潜力。然而，其在改善暴露前预防（PrEP）护理连续过程中的有效性尚未得到验证。本系统综述旨在评估数字健康干预措施在增强男男性行为者（MSM）群体中PrEP护理连续过程方面的有效性。
遵循PRISMA指南，对四个数据库——PubMed、科学网、Embase和考克兰图书馆进行了全面检索，以识别2024年7月2日前发表的随机对照试验（RCT）。在最初识别的3539条记录中，12项RCT符合纳入标准。大多数研究在美国进行（10/12，83.3%），其余2项研究在中国进行。参与者年龄在18至65岁之间。这些研究采用了各种数字健康工具，包括移动应用程序、短信和社交媒体平台。虽然发现数字健康干预措施是可行且可接受的，但只有少数研究显示PrEP利用率和依从性有统计学上的显著提高。数字健康干预措施已显示出增强MSM群体中PrEP护理连续过程的潜力。未来的研究应侧重于大规模、多中心试验，将数字工具与个性化、具有文化敏感性的策略相结合，以提高PrEP的接受率和依从性。整合大数据、人工智能（AI）以及社区外展和心理社会支持等非数字方法可以进一步增强这些干预措施的有效性。
