Department of Oncology, Kaizhou District People's Hospital of Chongqing, Chongqing, China.
Department of Osteology, Kaizhou District People's Hospital of Chongqing, Chongqing, China.
Med Oncol. 2022 May 15;39(5):72. doi: 10.1007/s12032-022-01669-0.
Renal cell carcinoma (RCC) is the most common form of malignancy affecting the kidneys. Circular RNAs (circRNAs) are non-coding RNAs that are derived from exonic or intronic sequences through a selective shearing process. There is growing evidence that these circRNAs can influence a range of biological pathways by serving as protein decoys, microRNA sponges, regulators of transcriptional activity, or templates for protein translation. The dysregulation of circRNA expression patterns is a hallmark of RCC and other cancer types, and there is strong evidence that these RNA species can play central roles in the onset and progression of RCC tumors. In the present review, we summarized recent findings on the functional roles and clinical impacts of circRNAs in RCC. Further, we discussed their potential utility as diagnostic biomarkers or targets for therapeutic intervention.
肾细胞癌（RCC）是最常见的影响肾脏的恶性肿瘤。环状 RNA（circRNA）是通过选择性剪接过程从外显子或内含子序列衍生而来的非编码 RNA。越来越多的证据表明，这些 circRNA 可以通过充当蛋白质诱饵、microRNA 海绵、转录活性调节剂或蛋白质翻译模板，影响一系列生物学途径。circRNA 表达模式的失调是 RCC 和其他癌症类型的标志，有强有力的证据表明这些 RNA 种类在 RCC 肿瘤的发生和进展中起着核心作用。在本综述中，我们总结了 circRNA 在 RCC 中的功能作用和临床影响的最新发现。此外，我们讨论了它们作为诊断生物标志物或治疗干预靶点的潜在用途。
