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人源性环状 RNA hsa_circRNA_101705（circTXNDC11）通过调节 MAPK/ERK 通路调控肾透明细胞癌的进展。

Human circular RNA hsa_circRNA_101705 (circTXNDC11) regulates renal cancer progression by regulating MAPK/ERK pathway.

机构信息

Department of Urology, Ninghai First Hospital, Zhejiang, China.

Department of Anesthesia, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

出版信息

Bioengineered. 2021 Dec;12(1):4432-4441. doi: 10.1080/21655979.2021.1955579.

DOI:10.1080/21655979.2021.1955579
PMID:34308775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8806623/
Abstract

Circular RNAs (circRNAs) play essential roles in the progression of human tumors, including renal cell carcinoma (RCC). The present study aimed to explore the functions and potential mechanisms of human circular RNA hsa_circRNA_101705 (circTXNDC11) in RCC. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to measure circTXNDC11 expression in RCC tissues and cell lines. RNase R and actinomycin D assays were conducted to analyze the characteristic of circTXNDC11. Cell Counting Kit-8 (CCK-8) assay, colony formation assay, and transwell invasion assay were performed to assess cell proliferation and invasion abilities. Western blotting was applied to assess the levels of MEK and ERK proteins in RCC cells. Murine xenograft model assay was conducted to deduce the role of circTXNDC11 in vivo. The current data showed that circTXNDC11 was overexpressed in RCC tissues and cells. The overexpression of circTXNDC11 is linked to advanced TNM stage and lymph node metastasis of renal cancer. Knocking down circTXNDC11 suppressed cell proliferation and invasion in vitro and reduced tumor growth in vivo. Mechanistically, circTXNDC11 promoted RCC growth and invasion by activating the MAPK/ERK pathway. Thus, the current findings identified circTXNDC11 as a novel regulator of RCC tumorigenesis through the regulation of the MAPK/ERK pathway, offering a potential therapeutic target for RCC treatment.

摘要

环状 RNA（circRNAs）在人类肿瘤的进展中发挥着重要作用，包括肾细胞癌（RCC）。本研究旨在探讨人环状 RNA hsa_circRNA_101705（circTXNDC11）在 RCC 中的功能和潜在机制。采用实时定量聚合酶链反应（qRT-PCR）测定 RCC 组织和细胞系中 circTXNDC11 的表达。采用 RNase R 和放线菌素 D 测定分析 circTXNDC11 的特征。通过细胞计数试剂盒-8（CCK-8）测定、集落形成测定和 Transwell 侵袭测定评估细胞增殖和侵袭能力。采用 Western blot 测定 RCC 细胞中 MEK 和 ERK 蛋白的水平。进行小鼠异种移植模型测定以推断 circTXNDC11 在体内的作用。目前的数据表明，circTXNDC11 在 RCC 组织和细胞中过度表达。circTXNDC11 的过表达与肾癌的晚期 TNM 分期和淋巴结转移有关。敲低 circTXNDC11 可抑制体外细胞增殖和侵袭，并减少体内肿瘤生长。机制上，circTXNDC11 通过激活 MAPK/ERK 通路促进 RCC 的生长和侵袭。因此，本研究发现 circTXNDC11 通过调节 MAPK/ERK 通路成为 RCC 肿瘤发生的新型调节因子，为 RCC 的治疗提供了潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/6f6d847f9f3d/KBIE_A_1955579_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/fc3cf4ebb85a/KBIE_A_1955579_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/e7b3bf9fe667/KBIE_A_1955579_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/113473ef0e83/KBIE_A_1955579_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/cee2a450a0f6/KBIE_A_1955579_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/c9ca08826118/KBIE_A_1955579_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/6f6d847f9f3d/KBIE_A_1955579_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/fc3cf4ebb85a/KBIE_A_1955579_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/e7b3bf9fe667/KBIE_A_1955579_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/113473ef0e83/KBIE_A_1955579_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/cee2a450a0f6/KBIE_A_1955579_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/c9ca08826118/KBIE_A_1955579_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ac/8806623/6f6d847f9f3d/KBIE_A_1955579_F0006_OC.jpg

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