School of Material Science and Engineering of Xihua University, Chengdu 610039, China.
Sichuan Institute for Drug Control, Chengdu 610017, China.
Int J Biol Macromol. 2022 Jun 30;211:460-469. doi: 10.1016/j.ijbiomac.2022.05.075. Epub 2022 May 13.
Poly(l-lactic acid) (PLLA) displays simultaneous repair and regeneration properties. Therefore, it is vital for developing bone repair materials while improving their mechanical strength, and biocompatibility is essential for guaranteeing its application. In this manuscript, using solid hot drawing (SHD) technology to fabricate an oriented shish-kebab like structure, furthermore, the interface-oriented grain boundary controlled the nucleation site and cell morphology during low temperature supercritical carbon dioxide (SC-CO) foaming process, resulted in an oriented microcellular structure which was similar to load-bearing bone. The tensile strength, elastic modulus, and elongation at break of the oriented microcellular PLLA were 98.4 MPa, 3.3 GPa, and 16.4%, respectively. Furthermore, the biomimetic structure improved osteoblast cells (MC3T3) attachment, proliferation, and propagation. These findings may pave the way for designing novel biomaterials for bone fixation or tissue engineering devices.
聚（L-乳酸）（PLLA）具有同时修复和再生的特性。因此，在开发骨修复材料时，提高其机械强度至关重要，而保证其应用的生物相容性也至关重要。在本文中，我们使用固体热拉伸（SHD）技术制造取向的 shish-kebab 样结构，此外，界面取向的晶界在低温超临界二氧化碳（SC-CO2）发泡过程中控制了成核位置和细胞形态，从而产生了类似于承重骨的取向微孔结构。取向微孔 PLLA 的拉伸强度、弹性模量和断裂伸长率分别为 98.4 MPa、3.3 GPa 和 16.4%。此外，仿生结构改善了成骨细胞（MC3T3）的附着、增殖和扩展。这些发现可能为设计用于骨固定或组织工程器械的新型生物材料铺平道路。
