风湿性疾病皮肤钙化病的管理。
Management of Calcinosis Cutis in Rheumatic Diseases.
机构信息
H. Elahmar, MD, Dermatologist at U-turn Dermatology Clinic, Kuwait City, Kuwait, and Dermatology and Venerology, Ain Shams University, Cairo, Egypt.
B.M. Feldman, MD, MSc, Pediatrics, Medicine, Institute of Health Policy Management and Evaluation, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada.
出版信息
J Rheumatol. 2022 Sep;49(9):980-989. doi: 10.3899/jrheum.211393. Epub 2022 May 15.
Calcinosis (hydroxyapatite and calcium phosphate crystal deposition) within the extracellular matrix of the dermis and subcutaneous tissue is a frequent manifestation of adult and pediatric systemic autoimmune rheumatic diseases, specifically systemic sclerosis, dermatomyositis, mixed connective tissue disease, and systemic lupus erythematosus. In this article, we review classification of calcinosis, highlight mechanisms that may contribute to the pathogenesis of calcinosis, and summarize the evidence evaluating nonpharmacologic and pharmacologic interventions for the treatment of calcinosis.
真皮和皮下组织细胞外基质中的钙沉积（羟磷灰石和磷酸钙晶体沉积）是成人和儿科系统性自身免疫性风湿病（尤其是系统性硬化症、皮肌炎、混合性结缔组织病和系统性红斑狼疮）的常见表现。本文综述了钙沉积的分类，强调了可能导致钙沉积发病机制的机制，并总结了评估钙沉积非药物和药物治疗干预措施的证据。
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