Barinov E F
Kardiologiia. 1978 Jul;18(7):112-6.
The state of intracardiac hemodynamics during normothermal perfusion was studied on an isolated heart-lung preparation obtained by the Robicsek I method (30 experiments). In appraisal of the hemodynamic and myocardial indices characterizing the functional condition of the right and left ventricles in 2 to 3 hours, definite changes were revealed which allowed prognostication of the duration and effectiveness of preservation. If the functional condition of the transplant (changes predominantly in the right ventricle) diminished in this period, heart arrest occurred within the next 30--60 minutes. If after these 2--3 hours the work of the heart-lung preparation was characterized by stationary parameters of intracardiac hemodynamics, such a transplant was capable of maintaining autoperfusion for 7 to 8 hours; the optimum term of preservation, however, was 6 hours. Irreparable diminution of the transplant viability occurred sharply in the next one or two hours.
在通过罗比切克I法获得的离体心肺标本上(30次实验),研究了常温灌注期间的心内血流动力学状态。在评估2至3小时内表征右心室和左心室功能状态的血流动力学和心肌指标时,发现了明确的变化,这些变化有助于预测保存的持续时间和效果。如果在此期间移植物的功能状态(主要是右心室的变化)下降,则在接下来的30至60分钟内心脏停搏。如果在这2至3小时后心肺标本的工作以心内血流动力学的稳定参数为特征,则这样的移植物能够维持自身灌注7至8小时;然而,最佳保存期限为6小时。在接下来的一两个小时内,移植物活力会急剧发生不可修复的下降。