完全交感神经切除术和去神经支配对犬移行性复合波的影响。

Effect of total sympathectomy and of decentralization on migrating complexes in dogs.

作者信息

Hashmonai M, Go V L, Szurszewski J H

出版信息

Gastroenterology. 1987 Apr;92(4):978-86. doi: 10.1016/0016-5085(87)90973-5.

Abstract

The effect of total sympathectomy and of decentralization on interdigestive myoelectric activity of the stomach and small intestine and on cycling levels of plasma motilin were studied in conscious dogs. In controls, 98.3% +/- 7.9% of the migrating myoelectric complexes (mean +/- SD) originated in the stomach. In sympathectomized dogs, 38.17% +/- 16.7% originated in the stomach, 35.8% +/- 12.3% in the duodenum, and 26.3% +/- 4.3% in the jejunum. In decentralized dogs, 5.3% +/- 1.4% of the migrating myoelectric complexes originated in the stomach, 71.0% +/- 16.5% in the duodenum, and 23.9% +/- 17.4% in the jejunum. Cycling of plasma motilin was not affected by long-term sympathectomy but coordination of peak levels of plasma motilin and initiation of gastric migrating myoelectric complexes was disrupted in decentralized dogs. These data suggest that central nervous input is required for initiation of migrating myoelectric complexes in the stomach and that central vagal but not central sympathectic input is essential for cycling of plasma motilin.

摘要

在清醒犬中研究了完全交感神经切除术和去神经支配对胃和小肠消化间期肌电活动以及血浆胃动素周期性水平的影响。在对照组中，98.3%±7.9%的移行性肌电复合波（均值±标准差）起源于胃。在交感神经切除的犬中，38.17%±16.7%起源于胃，35.8%±12.3%起源于十二指肠，26.3%±4.3%起源于空肠。在去神经支配的犬中，5.3%±1.4%的移行性肌电复合波起源于胃，71.0%±16.5%起源于十二指肠，23.9%±17.4%起源于空肠。长期交感神经切除术不影响血浆胃动素的周期性，但去神经支配的犬中血浆胃动素峰值水平与胃移行性肌电复合波起始的协调性受到破坏。这些数据表明胃中移行性肌电复合波的起始需要中枢神经输入，并且血浆胃动素的周期性变化中枢迷走神经而非中枢交感神经输入是必不可少的。