慢性美沙酮使用治疗阿片类药物成瘾的副作用：血液学紊乱的范围综述。

Side Effects of Chronic Methadone Use in Opioid Addiction: A Scoping Review on Hematological Derangements.

机构信息

Clinical Research Centre, Hospital Tuanku Fauziah, Perlis, Ministry of Health Malaysia, Malaysia.

Department of Psychiatry and Mental, Hospital Tuanku Fauziah, Jalan Kolam, Kangar, Perlis 01000, Malaysia.

出版信息

Curr Drug Saf. 2023;18(2):167-174. doi: 10.2174/1574886317666220514154931.

DOI:10.2174/1574886317666220514154931

PMID:35570535

Abstract

BACKGROUND

Per oral methadone maintenance therapy [MMT] was introduced as part of harm reduction strategy to manage rising numbers of HIV infections caused by intravenous use of illicit drugs.

METHOD

We aim to review published articles related to the side effects of long-term methadone therapy, focusing on hematological derangements in human studies published between 1 January 2000 till 31 January 2021.

RESULTS

Our search databases include Web of Science, Scopus, and Medline. Our search yielded 971 articles, of which 55 articles were related to the effects of MMT on various organ systems: cardiovascular [n=12], respiratory [n=1], endocrine [n=10], central nervous system [n=12], neurobehavioral [n=10], gastrointestinal [n=1], and bone [n=1]. There were eight articles specifically related to the hematological side effects of chronic methadone therapy that include [i] immune system hyperactivation, [ii] reduced circulating lymphocytes, and [iii] increased blood viscosity.

CONCLUSION

In view of all foreseeable health risks seen with prolonged methadone therapy, pharmacological modulation is warranted to find a better substitute for managing patients with opioid dependence.

摘要

背景

口服美沙酮维持治疗[MMT]作为减少伤害策略的一部分被引入，以管理因静脉使用非法药物而导致的艾滋病毒感染人数的上升。

方法

我们旨在回顾与长期美沙酮治疗相关的副作用的已发表文章，重点关注 2000 年 1 月 1 日至 2021 年 1 月 31 日期间发表的人类研究中的血液学紊乱。

结果

我们的搜索数据库包括 Web of Science、Scopus 和 Medline。我们的搜索结果产生了 971 篇文章，其中 55 篇文章与 MMT 对各种器官系统的影响有关：心血管[ n=12]、呼吸[n=1]、内分泌[n=10]、中枢神经系统[n=12]、神经行为[n=10]、胃肠道[n=1]和骨骼[n=1]。有 8 篇文章专门讨论了慢性美沙酮治疗的血液学副作用，包括[i]免疫系统过度激活、[ii]循环淋巴细胞减少和[iii]血液粘度增加。