Independent Researcher, Bhopal, Madhya Pradesh-462020, India.
Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh-462020. India.
Curr Mol Med. 2023;23(4):285-288. doi: 10.2174/1566524022666220513124853.
Hypoxia-inducible factors (HIFs) are a collection of transcriptional factors that engage in the regulation of oxygen homeostasis. They are hypoxia-responsive stress factors whose expression is linked to tumor growth and angiogenesis. HIF is a crucial player in the progression of breast cancer. Patients with high levels of hypoxia-inducible HIFs in their primary tumor biopsies had a higher chance of metastasis, the leading cause of breast cancer-related death. HIF polymorphisms have been shown in several epidemiological studies to influence breast cancer susceptibility. In the oxygendependent degradation domain, several short nucleotide polymorphisms (SNPs) of the HIF gene have been connected with higher HIF activity. To find SNP that make up the genetic diversity that underpins the phenotypic difference found between individuals in their susceptibility to cancer and the course of their disease, researchers used a variety of potential pathway-based approaches.
缺氧诱导因子（HIFs）是一组转录因子，参与调节氧稳态。它们是缺氧反应性应激因子，其表达与肿瘤生长和血管生成有关。HIF 是乳腺癌进展的关键因素。在原发性肿瘤活检中缺氧诱导 HIF 水平较高的患者，转移的可能性更高，而转移是导致乳腺癌相关死亡的主要原因。几项流行病学研究表明，HIF 多态性影响乳腺癌的易感性。在氧依赖的降解结构域中，HIF 基因的几个短核苷酸多态性（SNP）与较高的 HIF 活性有关。为了发现构成个体之间癌症易感性和疾病进程中表型差异的遗传多样性的 SNP，研究人员使用了多种潜在的基于通路的方法。
