From the Department of Surgical Sciences, Sapienza University, Rome, Italy.
Exp Clin Transplant. 2022 May;20(Suppl 3):27-35. doi: 10.6002/ect.PediatricSymp2022.L16.
Pediatric liver transplant is an established life-saving procedure for children with end-stage liver diseases, achieving excellent graft and patient survival but with effects on quality of life and psychological welfare in the long-term. With the natural increase in the number of pediatric transplant patients becoming adults, it is essential to successfully plan and manage issues affecting late outcomes in the vulnerable pediatric transplant population. This study offers an overview of the long-term surgical complications, the consequences of immunosuppression (such as posttransplant diabetes, hypertension, cardiovascular disease, and renal dysfunction), and the infection and malignancy risks. Finally, because quality of life is now an inclusive measurement of patient satisfaction, guidance on how to facilitate the transition to adulthood, empowering transplant recipients, is also provided.
儿科肝移植是治疗终末期肝病儿童的一种成熟的救命手术，在实现优异移植物和患者存活率的同时，也对长期生活质量和心理福祉产生影响。随着儿科肝移植患者数量的自然增长，成功规划和管理影响脆弱的儿科肝移植人群的晚期结局的问题至关重要。本研究概述了长期手术并发症、免疫抑制的后果（如移植后糖尿病、高血压、心血管疾病和肾功能障碍）以及感染和恶性肿瘤风险。最后，由于生活质量现在是患者满意度的综合衡量标准，还提供了如何促进向成年期过渡的指导，赋予移植受者权力。
