Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.
HCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Pathol Oncol Res. 2022 Apr 29;28:1610338. doi: 10.3389/pore.2022.1610338. eCollection 2022.
Hairy cell leukaemia (HCL) is a rare B cell malignancy with an indolent course leading to pancytopaenia due to bone marrow infiltration. It has been proposed that HCL patients are at risk of developing a secondary malignancy, with a marked likelihood of the development of other hematologic malignancies including Hodgkin lymphoma and high-grade non-Hodgkin lymphomas. Here, we present the case of two patients who developed diffuse large B cell lymphoma after a long course of hairy cell leukaemia. In the case of the female patient, we report on the occurrence of a third malignant disease, which is very uncommon. With our case descriptions we contribute to the very small number of similar cases reported.
毛细胞白血病（HCL）是一种罕见的 B 细胞恶性肿瘤，其病程呈惰性，由于骨髓浸润可导致全血细胞减少。据报道，HCL 患者存在发生继发性恶性肿瘤的风险，包括霍奇金淋巴瘤和高级别非霍奇金淋巴瘤等其他血液系统恶性肿瘤的发病风险明显增加。在这里，我们报告了两例长期患有毛细胞白血病后发展为弥漫性大 B 细胞淋巴瘤的患者。在女性患者的病例中，我们还报告了第三种恶性疾病的发生，这是非常罕见的。通过我们的病例描述，我们为为数不多的类似病例报道做出了贡献。
