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Threshold of Toxicological Concern: Extending the chemical space by inclusion of a highly curated dataset for organosilicon compounds.毒理学关注阈值：通过包含经过高度策展的有机硅化合物数据集来扩展化学空间。
Regul Toxicol Pharmacol. 2021 Dec;127:105074. doi: 10.1016/j.yrtph.2021.105074. Epub 2021 Oct 30.
2
The SCCS Notes of Guidance for the testing of cosmetic ingredients and their safety evaluation, 11th revision, 30-31 March 2021, SCCS/1628/21.SCCS 化妆品成分测试和安全性评估指导原则注释，第 11 修订版，2021 年 3 月 30 日至 31 日，SCCS/1628/21。
Regul Toxicol Pharmacol. 2021 Dec;127:105052. doi: 10.1016/j.yrtph.2021.105052. Epub 2021 Oct 13.
3
The Threshold of Toxicological Concern (TTC) is a pragmatic tool for the safety assessment: Case studies of cosmetic ingredients with low consumer exposure.毒理学关注阈值（TTC）是用于安全性评估的实用工具：低消费者暴露量化妆品成分的案例研究
Regul Toxicol Pharmacol. 2021 Jul;123:104964. doi: 10.1016/j.yrtph.2021.104964. Epub 2021 May 21.
4
Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment.食品安全评估中毒理学关注阈值方法的使用指南。
EFSA J. 2019 Jun 6;17(6):e05708. doi: 10.2903/j.efsa.2019.5708. eCollection 2019 Jun.
5
Bolstering the existing database supporting the non-cancer Threshold of Toxicological Concern values with toxicity data on fragrance-related materials.用与香料相关的物质的毒性数据来支持现有的非癌症毒理学关注阈值的现有数据库。
Regul Toxicol Pharmacol. 2020 Oct;116:104718. doi: 10.1016/j.yrtph.2020.104718. Epub 2020 Jun 27.
6
Threshold of toxicological concern (TTC) for botanicals - Concentration data analysis of potentially genotoxic constituents to substantiate and extend the TTC approach to botanicals.毒理学关注阈值 (TTC) 用于植物药 - 潜在遗传毒性成分的浓度数据分析，以证实和扩展 TTC 方法在植物药中的应用。
Food Chem Toxicol. 2020 Apr;138:111182. doi: 10.1016/j.fct.2020.111182. Epub 2020 Feb 10.
7
Evaluating potential refinements to existing Threshold of Toxicological Concern (TTC) values for environmentally-relevant compounds.评估现有毒理学关注阈值 (TTC) 值在环境相关化合物方面的潜在改进。
Regul Toxicol Pharmacol. 2019 Dec;109:104505. doi: 10.1016/j.yrtph.2019.104505. Epub 2019 Oct 19.
8
Threshold of Toxicological Concern (TTC) for Botanical Extracts (Botanical-TTC) derived from a meta-analysis of repeated-dose toxicity studies.毒理学关注阈值（TTC）用于植物提取物（植物-TTC），来源于重复剂量毒性研究的荟萃分析。
Toxicol Lett. 2019 Nov;316:1-9. doi: 10.1016/j.toxlet.2019.08.006. Epub 2019 Aug 12.
9
Testing the thresholds of toxicological concern values using a new database for food-related substances.利用新的食品相关物质数据库测试毒理学关注阈值。
Toxicol Lett. 2019 Oct 10;314:117-123. doi: 10.1016/j.toxlet.2019.07.019. Epub 2019 Jul 17.
10
Multi-Detector Characterization of Grape Seed Extract to Enable Safety Assessment.葡萄籽提取物的多探测器表征以实现安全性评估。
Front Chem. 2018 Aug 14;6:334. doi: 10.3389/fchem.2018.00334. eCollection 2018.

Editorial: Advances and Refinements in the Development and Application of Threshold of Toxicological Concern.

作者信息

Patlewicz Grace, Worth Andrew, Yang Chihae, Zhu Tingting

机构信息

Independent Researcher, Durham, NC, United States.

European Commission, Joint Research Centre (JRC), Ispra, Italy.

出版信息

Front Toxicol. 2022 Apr 28;4:882321. doi: 10.3389/ftox.2022.882321. eCollection 2022.

DOI:10.3389/ftox.2022.882321
PMID:35573274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9096208/
Abstract
摘要