Kapatia Gargi, Chatterjee Debajyoti, Gupta Kirti, Trehan Amita
Post Graduate Institute of Medical Education & Research, Department of Histopathology, Chandigarh, India.
Post Graduate Institute of Medical Education & Research, Department of Pediatrics, Chandigarh, India.
Autops Case Rep. 2022 Apr 28;12:e2021380. doi: 10.4322/acr.2021.380. eCollection 2022.
Fibrous hamartoma of infancy (FHI) is a rare soft tissue lesion arising as a subcutaneous mass involving the axilla, trunk, and upper arm in infants and children <2yrs. Sarcomatous transformation in FHI is described in anecdotal cases in the literature.
We describe one such example arising as a mass in the lower back in a 3-month-old infant. On histology, the tumor contained classic triphasic morphology; however, brisk mitotic activity noted at multiple foci was diagnostically challenging to categorize. The tumor was evaluated for fusion to exclude other common differentials.
While FHI may be frequently encountered in infants, rare sarcomatous transformation are known to occur and merits special attention as it can be misdiagnosed. Also, a close follow-up is warranted as the lesion is known to recur locally.
婴儿纤维性错构瘤（FHI）是一种罕见的软组织病变，表现为皮下肿块，累及2岁以下婴幼儿的腋窝、躯干和上臂。文献中有关于FHI发生肉瘤样变的个别病例报道。
我们描述了一个这样的病例，一名3个月大的婴儿下背部出现肿块。组织学检查显示，肿瘤具有典型的三相形态；然而，在多个病灶处观察到的活跃有丝分裂活动在诊断分类上具有挑战性。对该肿瘤进行了融合评估以排除其他常见鉴别诊断。
虽然FHI在婴儿中可能经常遇到，但已知会发生罕见的肉瘤样变，由于可能被误诊，值得特别关注。此外，鉴于已知该病变会局部复发，因此有必要进行密切随访。
