Ghosh Subrata, Singh Pushpendra, Manna Jhimli, Saxena Komal, Sahoo Pathik, Krishnanda Soami Daya, Ray Kanad, Hill Jonathan P, Bandyopadhyay Anirban
Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, NEIST, Jorhat, India.
Academy of Scientific and Innovative Research (ACSIR), Ghaziabad, India.
Commun Integr Biol. 2022 May 10;15(1):115-120. doi: 10.1080/19420889.2022.2071101. eCollection 2022.
In 1907, Lapicque proposed that an electric field passes through the neuronal membrane and transmits a signal. Subsequently, a "snake curve" or spike was used to depict the means by which a linear flat current undergoes a sudden Gaussian or Laplacian peak. This concept has been the accepted scenario for more than 115 years even appearing in textbooks on the subject. It was not noted that the membrane spike should have a cylindrical shape. A nerve spike having a dot shape on membrane surface cannot propagate through a cylindrical surface since it would dissipate instantaneously. A nerve spike should have the appearance of a ring, encompassing the diameter of a cylindrical axon or dendron. However, this subtle change has remarkable implications. Maintaining a circular form of an electric field is not easy, especially at the surface of an organic object. Here, we suggest that neuroscience could redefine itself if we accept that a nerve spike is not a localized 3D Gaussian or Laplacian wave packet, rather it is a 3D ring encompassing the diameter of a neural branch.
1907年，拉皮克提出电场穿过神经元膜并传递信号。随后，用“蛇形曲线”或尖峰来描述线性平面电流经历突然的高斯或拉普拉斯峰的方式。这个概念在超过115年的时间里一直是被接受的情形，甚至出现在关于该主题的教科书中。人们没有注意到膜尖峰应该具有圆柱形形状。在膜表面具有点状形状的神经尖峰不能通过圆柱形表面传播，因为它会瞬间消散。神经尖峰应该呈现为一个环的样子，环绕着圆柱形轴突或树突的直径。然而，这种细微的变化具有显著的意义。维持电场的圆形形式并不容易，尤其是在有机物体的表面。在这里，我们认为，如果我们接受神经尖峰不是局部的三维高斯或拉普拉斯波包，而是一个环绕神经分支直径的三维环，那么神经科学可能会重新定义自身。
